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1. (Article ID: 7702)
Román Y, de Oliveira Barddal HP, Iacomini M, Sassaki GL, Cipriani TR
Anticoagulant and antithrombotic effects of chemically sulfated fucogalactan and citrus pectin
Carbohydrate Polymers 174 (2017)
731-739
Citrus pectin (CP14) from Citrus sinensis, and a fucogalactan (E) and a glucan (G16) from Agaricus bisporus were isolated and structurally characterized. CP14 was constituted by (1→4)-linked α-D-GalpA units, E was composed by a (1→6)-linked α-D-Galp main-chain, partially substituted at O-2 by non-reducing end-units of α-L-Fucp or α-D-Galp, and partially methylated at O-3, whereas G16 was composed of (1→6)-linked β-D-Glcp units. The polysaccharides were sulfated giving rise to CP14S, ESL and G16S. The APTT and PT assays showed a decreasing order of anticoagulant activity for ESL, CP14S and G16S, respectively. ESL and CP14S showed greater anticoagulant activity. However, ESL reduced thrombus formation to 32.3% at a dose of 6.0 mg/kg, whereas CP14S inhibited totally the thrombus formation at 3.0mg/kg, in vivo. NMR and methylation analyses showed that α-D-GalAp units of CP14S were sulfated in 2,3-O-position, whereas ESL was mainly sulfated in 2-O-, 2,3-O- and 2,3,4-O-positions.
anticoagulant activity, fucogalactan, antithrombotic activity, chemical sulfation, citrus pectin
NCBI PubMed ID: 28821126Publication DOI: 10.1016/j.carbpol.2017.06.110Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: Román Y
yahoo.com>; Cipriani TR ufpr.br>; Cipriani TR hotmail.com>
Institutions: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Brazil
Methods: 13C NMR, 1H NMR, HPSEC, acetylation, methylation analysis, reduction with NaBH4, GS-MS, HSQC, TFA hydrolysis, HSQC-DEPT, SO3-pyridine sulfation
The publication contains the following compound(s):
- Compound ID: 19535
|
a-L-Fucp-(1-2)-+
|
-6)-a-D-Galp-(1-6)-a-D-Galp-(1-6)-a-D-Galp-(1-6)-a-D-Galp-(1-6)-a-D-Galp3Me-(1-6)-a-D-Galp-(1- |
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Structure type: structural motif or average structure
; 12800
Trivial name: fucogalactan
Reference(s) to other database(s): GTC:G66022JJ
- Compound ID: 19536
Structure type: homopolymer
; 82600
Trivial name: β-(1→6)-D-glucan (B16)
Compound class: glucan
Reference(s) to other database(s): GTC:G26777BZ
- Compound ID: 28448
|
S-2)-+ S-2)-+
| |
-4)-a-D-GalpA6(34%)Me-(1-4)-a-D-GalpA-(1-
| |
S-3)-+ S-3)-+ |
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Structure type: structural motif or average structure
; 124000
Compound class: polysaccharide
Reference(s) to other database(s): GTC:G79627DV
- Compound ID: 28447
Structure type: structural motif or average structure
; 417000
Trivial name: pectin
Reference(s) to other database(s): GTC:G95099AN
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2. (Article ID: 8187)
He J, Zhang A, Ru Q, Dong D, Sun P
Structural characterization of a water-soluble polysaccharide from the fruiting bodies of Agaricus bisporus
International Journal of Molecular Sciences 15(1) (2014)
787-797
An edible fungal polysaccharide termed as ABP was obtained by extraction with hot water, and followed successive chromatographic purification using DEAE-Sepharose Fast Flow column and Sephacryl S-300 High-Resolution column. A symmetrical peak was obtained on high-performance size-exclusion chromatography with an average molecular weight of 5.17 × 10(4) Da, which was named ABP, and its main components were D-glucose and D-mannose. Based on the study of methylation analysis, along with FT-IR, GC, GC-MS, 1D 1H and 13C NMR and 2D NMR (H-HCOSY, TOCSY, HMQC, and NOESY), its chemical structure was featured with a repeating unit (1→6) linking β-D-Glcp as the main backbone with (1→4)-linked α-D-Manp units. The structure of the mainly repeating units of ABP was established as: →6)-β-D-Glcp-(1→4)-α-D-Manp(1→6)-β-D-Glcp-(1→6)-β-D-Glcp-(1→.
polysaccharide, Structural characterization, NMR spectrum, Agaricus bisporus
NCBI PubMed ID: 24406732Publication DOI: 10.3390/ijms15010787Journal NLM ID: 101092791Publisher: Basel, Switzerland: MDPI
Correspondence: He J
163.com>; Zhang A zjut.edu.cn>; Ru Q zjut.edu.cn>; Dong D aliyun.com>; Sun P 163.com>
Institutions: College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, China, Yuhang District Agricultural Monitoring Centre of Hangzhou, Hangzhou, China
Methods: 13C NMR, 1H NMR, IR, GC-MS, HPLC, GPC, HPSEC, acetylation, TOCSY, methylation analysis, reduction with NaBH4, GC-FID, HMBC, HMQC, COSY, NOESY, FT-IR, TFA hydrolysis
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