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1. (Article ID: 7703)
Zhao JL, Zhang M, Liu JM, Tan Z, Chen RD, Xie KB, Dai JG
Bioactive steroids and sorbicillinoids isolated from the endophytic fungus Trichoderma sp. Xy24
Journal of Asian Natural Products Research 19(10) (2017)
1028-1035
A new steroid glucoside (1), along with nine known steroids (2-10) and four known sorbicillinoids (11-14), were isolated from the endophytic fungus Trichoderma sp. Xy24. Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with reported data. Compounds 3, 5-7, 9, 10, and 13 exhibited significant inhibitory effects on HIV-1 virus with IC50 values ranging 1.9-9.3 μM; compounds 10, 13, and 14 showed potent inhibitory activity on LPS-induced NO production in BV2 microglia cells with inhibitory rates of 108.2, 100, and 75.1% at 10 μM, respectively. In addition, compound 10 displayed moderate cytotoxicity against BCG823 and HePG2 cell lines with IC50 values of 11.1 and 17.7 μM, respectively.
cytotoxicity, steroids, anti-inflammatory activity, Trichoderma sp. Xy24, anti-HIV activity, sorbicillinoids
NCBI PubMed ID: 28145126Publication DOI: 10.1080/10286020.2017.1285908Journal NLM ID: 100888334Publisher: Harwood Academic Publishers; London: Informa Healthcare
Correspondence: jgdai
imm.ac.cn
Institutions: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Methods: 13C NMR, 1H NMR, IR, TLC, acid hydrolysis, HPLC, optical rotation measurement, HR-ESI-MS, HMBC, DEPT, NOESY, HSQC
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