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1. (Article ID: 7706)
 
Helaly SE, Kuephadungphan W, Phongpaichit S, Luangsa-ard JJ, Rukachaisirikul V, Stadler M
Five unprecedented secondary metabolites from the spider parasitic fungus Akanthomyces novoguineensis
Molecules 22 (2017) e991
 

Five new compounds including the glycosylated β-naphthol (1, akanthol), a glycosylated pyrazine (2, akanthozine), and three amide derivatives including a hydroxamic acid derivative (3-5) were isolated from the spider-associated fungus Akanthomyces novoguineensis (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of A. novoguineensis were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by A. novoguineensis

chemotaxonomy, hydroxamic acid, Akanthomyces novoguineensis, akanthol, akanthozine

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2. (Article ID: 7708)
 
Kuephadungphan W, Helaly SE, Daengrot C, Phongpaichit S, Luangsa-ard JJ, Rukachaisirikul V, Stadler M
Akanthopyrones A-D, α-pyrones bearing a 4-O-methyl-β-D-glucopyranose moiety from the spider-associated ascomycete Akanthomyces novoguineensis
Molecules 22(7) (2017) e1202
 

Hypocrealean fungi have proved to be prolific bioactive metabolite producers; they have caught the attention of mycologists throughout the world. However, only a few studies on the insect and spider parasitic genus Akanthomyces have so far been carried out. In this study, we report the isolation, structural elucidation and biological activities of four unprecedented glycosylated α-pyrone derivatives, akanthopyrones A-D (1-4), from a culture of Akanthomyces novoguineensis collected in Thailand. The chemical structures of the akanthopyrones were determined by extensive 1D- and 2D-NMR, and HRMS spectroscopic analysis. Their absolute configurations were determined. Akanthopyrone A (1) exhibited weak antimicrobial activity against Bacillus subtilis DSM10 and cytotoxicity against the HeLa cell line KB-3-1, while akanthopyrone D (4) showed weak activity against Candida tenuis MUCL 29892.

Hypocreales, cordycipitaceae, invertebrate-associated fungi, α-pyrones, 4-O-methy-β-D-glucopyranose, 4-O-methyl-β-D-glucopyranose

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