Two new compounds named fischeacid and fischexanthone, together with eight known compounds, were obtained from the culture of a marine-derived fungus Neosartorya fischeri strain 1008F1. The structures of the new compounds were elucidated based on the spectroscopic data. Bioassays indicated that AGI-B4 and 3,4-dihydroxybenzoic acid showed potent inhibitory effect on the replication of tobacco mosaic virus, and AGI-B4 also possessed an inhibition of the cell proliferation of human gastric cancer cell line SGC-7901 and hepatic cancer cells BEL-7404.

cytotoxicity, Neosartorya fischeri, fischeacid, fischexanthone, antiphytoviral effect

NCBI PubMed ID: 21916772
Publication DOI: 10.1080/14786419.2011.592834
Journal NLM ID: 101167924
Publisher: Milton Park, UK : Taylor & Francis Health Sciences
Correspondence: maouyanghqu.edu.cn
Institutions: Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, China, Institute of Biotechnology, Qinghai Academy of Agriculture and Forestry, Xining, China
Methods: 13C NMR, 1H NMR, NMR-2D, IR, FAB-MS, TLC, UV, extraction, gel chromatography, optical rotation measurement, CC, cell growth
 

• Compound ID: 19877
  

  b-D-Sug5Me-(1-9)-Subst Sug = 5-amino-5-deoxy-D-ribofuranose = SMILES O{5}C[C@H]1O{1}[C@@H](O)[C@H](O)[C@@H]1O; Subst = adenine = SMILES Nc1ncnc2{9}[nH]cnc12

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  Structure type: monomer
  Trivial name: 5'-deoxy-5'-methylamino-adenosine
  Compound class: glycoside
  Reference(s) to other database(s): GenDB: EU926976
  
   
  
  Neosartorya fischeri 1008F1
  CSDB ID 45908 (all data & tools)
• Compound ID: 19878
  

  A	Show graphically

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  Structure type: monomer
  Trivial name: adenosine, Adenosine
  Compound class: glycoside, flavonoid glycoside, nucleoside
  Reference(s) to other database(s): GenDB: EU926976
  
   
  
  Neosartorya fischeri 1008F1
  CSDB ID 45909 (all data & tools)