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1. (Article ID: 7859)
Yin H, Lv X, Wang Y, Gao H, Wang M
Protection of chronic renal failure by a polysaccharide from Cordyceps sinensis
Fitoterapia 81(5) (2010)
397-402
A water-soluble polysaccharide (CPS-2), isolated from the cultured Cordyceps sinensis, was obtained by hot-water extraction, anion-exchange and gel permeation chromatography. Its structural characteristics were investigated by PMP pre-column derivation, periodate oxidation, methylation analysis, FTIR and NMR spectroscopy. CPS-2 was found to be mostly of α-(1→4)-D-glucose and α-(1→3)-D-mannose, branched with α-(1→4,6)-D-glucose every twelve residues on average. CPS-2 had a molecular weight of 43900 Da. The protective effect of CPS-2 on the model of chronic renal failure was established by fulgerizing kidney. The changes in blood urea nitrogen and serum creatinine revealed that CPS-2 could significantly relieve renal failure caused by fulgerizing kidney.
structure characterization, Cordyceps sinensis polysaccharide, renal injury
NCBI PubMed ID: 19969045Publication DOI: 10.1016/j.fitote.2009.11.008Journal NLM ID: 16930290RPublisher: Elsevier
Correspondence: Yin H
hotmail.com>; Wang M cpu.edu.cn>
Institutions: School of Life Science and Technology, China Pharmaceutical University, Nanjing, China, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
Methods: 13C NMR, 1H NMR, methylation, periodate oxidation, IR, GC-MS, acid hydrolysis, Smith degradation, biological assays, FTIR, HPLC, ion-exchange chromatography, extraction, acetylation, elemental analysis, methylation analysis, NaBH4 reduction, reduction, CC, cell growth, HPGPC, phenol-sulfuric acid assay, Sevag method, centrifugation
The publication contains the following compound(s):
- Compound ID: 19883
|
a-D-Manp-(1-6)-+ a-D-Glcp-(1-6)-+
| |
-4)-a-D-Glcp-(1-3)-{{{-a-D-Manp-(1-3)-}}}/n=2/-a-D-Manp-(1-4)-{{{-a-D-Glcp-(1-4)-}}}/n=9/-a-D-Glcp-(1- |
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Structure type: structural motif or average structure
; 43900
Compound class: O-polysaccharide, glucomannan
- Compound ID: 20040
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a-D-Manp-(1-6)-+ a-D-Galp-(1-6)-+
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-4)-a-D-Glcp-(1-3)-a-D-Manp-(1-3)-a-D-Manp-(1-3)-a-D-Manp-(1-4)-{{{-a-D-Glcp-(1-4)-}}}/n=9/-a-D-Glcp-(1- |
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Structure type: structural motif or average structure
; 43900
Compound class: galactoglucomannan
Reference(s) to other database(s): GTC:G77855UW
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