The relationship between mold and asthma has been recognized for decades, but the molecular triggers of asthma generated by molds have not been fully elucidated. A glycolipid generated by Aspergillus species has recently been identified that triggers airway hyperreactivity via natural killer T cell activation. The synthesis of this glycolipid and structural variants designed to allow identification of the features of this glycolipid required for recognition by natural killer T cells is described.
NCBI PubMed ID: 24111801Publication DOI: 10.1021/ol4024375Journal NLM ID: 100890393Publisher: American Chemical Society
Correspondence: paul_savage
byu.edu
Institutions: Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA, Division of Immunology and Allergy, Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Methods: 13C NMR, 1H NMR, ELISA, HR-ESI-MS, silica gel chromatography
Found