Found 2 publications. Displayed publications from 1 to 2
Expand all publications       Show all as text (SweetDB notation)
1. (Article ID: 7984)
 
Tronina T, Bartmańska A, Milczarek M, Wietrzyk J, Popłoński J, Rój E, Huszcza E
Antioxidant and antiproliferative activity of glycosides obtained by biotransformation of xanthohumol
Bioorganic and Medicinal Chemistry Letters 23(7) (2013) 1957-1960
 

The biotransformation of xanthohumol (1), a prenylated chalcone isolated from hops by selected fungi, was investigated. Microbial regioselective glycosylation at the C-4' position led to xanthohumol 4'-O-β-D-glucopyranoside (2) and xanthohumol 4'-O-β-D-(4'''-O-methyl)-glucopyranoside (3). The subsequent cyclization of 2 resulted in isoxanthohumol 7-O-β-glucopyranoside (4). The structures of the products were identified based on spectroscopic methods. The biological activity of isolated metabolites has been evaluated. Compared to xanthohumol (1), metabolite 2 is a better 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenger, while 2 and 3 have stronger antiproliferative activity against the human HT-29 colon cancer cell line.

glycosylation, Antioxidant activity, Antiproliferative activity, biotransformation, xanthohumol, spent hops

The publication contains the following compound(s):
 

Expand this publication
2. (Article ID: 8631)
 
Sordon S, Popłoński J, Huszcza E
Microbial glycosylation of flavonoids
Polish Journal of Microbiology 65(2) (2016) 137-151
 

Flavonoids constitute a large group of polyphenolic compounds naturally found in plants, which have a wide range of biological activity. Although flavonoids are beneficial to human health, their application is limited by their low bioavailability and poor water-solubility. Therefore, recently there has been a particular interest in glycosylated forms of flavonoids, which usually are better soluble, more stable, and more functional compared to their aglycones. Microbial transformation of natural flavonoids may be an attractive way of receiving their glycosylated derivatives in amounts sufficient for the research on the effect of glycoside group on compound properties and for further application of these compounds as ingredients of dietary supplements and pharmaceuticals.

glycosides, biotransformation, microbial glycosylation, flavonoids

The publication contains the following compound(s):
 

Expand this publication

Resort publications by:

New query Export IDs Home Help

Execution: <1 sec