Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Salmonella enterica [ICD11:
XN5VC 
]
Publication DOI: 10.1080/07328309808002363Journal NLM ID: 8218151Publisher: Marcel Dekker
Institutions: Ribi ImmunoChem Research, Inc., Pharmaceutical Discovery Division 553 Old Corvallis Rd., Hamilton, MT 59840 USA
Structural investigations have shown that lipid A constitutes the active principle of lipopoly saccharide (LPS, endotoxin), a complex amphipathic molecule located on the cell surface of Gram-negative bacteria.1 Lipid A elicits not only the typical endotoxic reactions such as fever and lethal shock but also adjuvant, antitumor and other beneficial effects.1 As a result, there has been a great deal of interest in the synthesis of lipid A derivatives possessing low toxicity.
synthesis, lipid A, Salmonella, chemical synthesis, Salmonella minnesota, monophosphoryl lipid A
Structure type: oligomer
Location inside paper: p.1422, compound 1
Compound class: lipid A
Contained glycoepitopes: IEDB_135394,IEDB_135515,IEDB_141181,IEDB_141807,IEDB_151531,IEDB_176772,IEDB_534864
Methods: 13C NMR, 1H NMR, FAB-MS, TLC, chemical synthesis, chemical methods, HPLC
Related record ID(s): 31396, 31397
NCBI Taxonomy refs (TaxIDs): 70803
Show glycosyltransferases
There is only one chemically distinct structure:
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(later renamed to: Salmonella enterica ssp. enterica sv. Minnesota R595)