Consumption of edible mushrooms has been practiced since ages to promote human health and as traditional remedies for multiple human ailments. The excellent nutritional quality of these organisms collectively called as filamentous fungi for their filament like hyphal extension, owes to a high protein, low fat and cholesterol free profile. Over the last decade, a diverse repertoire of protein-glycan conjugates isolated from these organisms has been attributed with immunomodulatory, anticancer, and other therapeutic activities. An integrated use of conventional chemical analyses, improved separation technologies, and new generation high-throughput proteomic approaches has revealed features in these complex biomolecules unknown elsewhere amongst the eukaryotes. However, due to some serious technological bottlenecks, a comprehensive structure-function delineation of the fungal glycoproteome has eluded the scientists. If we can prevail over these constraints and dig deep into this unique niche of the fungal kingdom, the quest for new generation nutraceuticals and therapeutics will get headway.

glycoproteins, mushrooms, Glycoproteomics, filamentous fungi, polysaccharopeptide complexes, nutraceuticals, therapeutic enzymes

• Compound ID: 20471
  

  /Variants 0/-+ | -3)-b-D-Glcp-(1- /Variants 0/ is: b-D-Glcp-(1-6)- OR (exclusively) b-D-Glcp-(1-2)-

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  Structure type: structural motif or average structure
  Compound class: cell wall polysaccharide, glucan
  
   
  
  Poria cocos
  CSDB ID 42498 (all data & tools)
• Compound ID: 16857
  

  b-D-Glcp-(1-6)-+ | -3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-

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  Structure type: polymer chemical repeating unit
  Trivial name: β-D-glucan, β-glucan, schizophyllan, carboxymethylglucan, pleuran, scleroglucan, lentinan, GRN, SPG, sizofiran, shizophyllan, Scleroglucan, lentinan-type beta-glucans (Ths-2), b-(1-3,6)-glucan, HEP3, grifolan LE, schizophyllan, scleroglucan, lentinan, termitan, grifolan, schizophyllan, scleroglucan, schizophyllan, sizofiran, grifolan, scleroglucan, schizophyllan, sonifilan, schizophyllan, grifolan, G. frondosa polysaccharide (GFP), alkali-soluble β-glucan (PeA3), schizophyllan (SPG), β-glucan, schizophyllan, β-glucan, schizophyllan, scleroglucan, pleuran
  Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glucan, polysaccharide, β-glucan, b-glucan, scleroglucan, D-glucan
  Reference(s) to other database(s): GTC:G66305IS, CCSD:49943, CBank-STR:12679, CA:9050-67-3
  
   
  
  Grifola frondosa, Schizophyllum commune, Sclerotinia sclerotiorum
  CSDB ID 42490 (all data & tools)
• Compound ID: 13319
  

  -3)-a-D-Glcp-(1-

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  Structure type: homopolymer
  Trivial name: D-rhamnan, α-1,3-D-glucan, α-1,3-glucan, (1-3)-α-Glucan, 1-3-α-glucan, α-(1,3)-glucan, α-(1,3)glucan, (1-3)-α-glucan, pseudonigeran, α-(1,3)-glucan, pseudonigeran, water-insoluble α-D-glucan (TM-I)
  Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glucan, polysaccharide, D-glucan
  Reference(s) to other database(s): GTC:G02177KX, CCSD:49417, CBank-STR:17683, GenDB:HM245773
  
   
  
  Amanita muscaria, Agrocybe aegerita, Armillariella tabescens
  CSDB ID 48502 (all data & tools)
• Compound ID: 20469
  

  ?%b-D-Glcp-(1-3)-+ | -6)-b-D-Glcp-(1-

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  Structure type: structural motif or average structure
  Compound class: cell wall polysaccharide, glucan
  Reference(s) to other database(s): GTC:G62549JW
  
   
  
  Grifola frondosa, Agaricus blazei
  CSDB ID 42489 (all data & tools)
• Compound ID: 20472
  

  ?%b-D-Glcp-(1-6)-+ | -3)-a-D-Glcp-(1-

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  Structure type: structural motif or average structure
  Compound class: cell wall polysaccharide, glucan
  Reference(s) to other database(s): GTC:G98920VJ
  
   
  
  Agaricus blazei
  CSDB ID 42500 (all data & tools)
• Compound ID: 20473
  

  ?%a-D-Glcp-(1-4)-+ | -6)-a-D-Glcp-(1-

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  Structure type: structural motif or average structure
  Compound class: cell wall polysaccharide, glucan
  Reference(s) to other database(s): GTC:G35539RB
  
   
  
  Agaricus blazei
  CSDB ID 48501 (all data & tools)
• Compound ID: 19239
  

  b-D-Glcp-(1-6)-+ b-D-Glcp-(1-6)-+ | | -3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-

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  Structure type: polymer chemical repeating unit ; 500000
  Trivial name: lentinan
  Compound class: O-polysaccharide, cell wall polysaccharide, glucan
  Reference(s) to other database(s): GTC:G14698DR
  
   
  
  Lentinula edodes
  CSDB ID 42492 (all data & tools)
• Compound ID: 20470
  

  34%b-D-Glcp-(1-6)-b-D-Glcp-(1-6)-b-D-Glcp-(1-6)-+ | 33%b-D-Glcp-(1-6)-b-D-Glcp-(1-6)-b-D-Glcp-(1-6)-+ | | | -4)-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-{{{-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-}}}/n=2/-b-D-Glcp-(1-

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  Structure type: structural motif or average structure
  Trivial name: grifolan
  Compound class: cell wall polysaccharide, glucan, polysaccharide
  
   
  
  Grifola frondosa
  CSDB ID 42491 (all data & tools)
• Compound ID: 20305
  

  ?%b-D-Glcp-(1-6)-+ | -3)-b-D-Glcp-(1-

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  Structure type: structural motif or average structure
  Trivial name: pachyman, sparan, polycan
  Compound class: EPS, cell wall polysaccharide, glucan, polysaccharide
  Reference(s) to other database(s): GTC:G83138WS
  
   
  
  Ganoderma lucidum, Cordyceps militaris
  CSDB ID 42488 (all data & tools)
• Compound ID: 6167
  

  -6)-b-D-Glcp-(1-

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  Structure type: homopolymer
  Trivial name: pustulan, β-1,6-glucan, β-1,6-D-glucan, β(1-6)-D-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-(1,6)-glucan, lasiodiplodan, β-(1,6)-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-1,6-glucan, β-(1,6)-glucan, pustulan, β-(1→6)-glucan PCPS, water-soluble glucan (PS-I)
  Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glycoprotein, glucan, polysaccharide, cell wall glucoprotein
  Reference(s) to other database(s): GTC:G26777BZ, GlycomeDB:863, CCSD:50854, CBank-STR:4234
  
   
  
  Armillariella tabescens, Lyophyllum decastes
  CSDB ID 42499 (all data & tools)
• Compound ID: 4415
  

  -3)-b-D-Glcp-(1-

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  Structure type: homopolymer
  Trivial name: glucan, β-1,3-glucan, curdlan, curdlan-type polysaccharide 13140, paramylon, curdlan, laminarin, β-glucan, curdlan, β-(1,3)-glucan, β-(1,3)-glucan, curdlan, curdlan, β-1,3-glucan, paramylon, reserve polysaccharide, b-glucan, β-1,3-D-glucan, laminaran, botryosphaeran, laminaran type β-D-glucan, latiglucan I, pachymaran, Curdlan, zymosan A, β-glucan, curdlan, laminarin, zymosan, zymosan, glucan particles, zymosan, β-(1-3)-glucan, β-(1,3)-glucan, β-(1,3)glucan, pachymaran, D-glucan (DPn)540, pachyman, laminaran, curdlan, zymosan, zymosan, β-(1,3)-glucan, zymosan A, zymosan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, pachyman, β-(1,3)-glucan, curdlan, callose, a water-insoluble β-(1→3)-glucan, fermentum β-polysaccharide, water-insoluble glucan, alkali-soluble β-glucan (PeA3), alkali-soluble polysaccharide (PCAP), callose, laminarin
  Compound class: EPS, O-polysaccharide, cell wall polysaccharide, lipophosphoglycan, glycoprotein, LPG, glucan, polysaccharide, glycoside, β-glucan, β3-glucan, cell wall glucan
  Reference(s) to other database(s): GTC:G51056AN, GlycomeDB:157, CCSD:50049, CBank-STR:4225, CA-RN: 51052-65-4, GenDB:FJ3380871.1
  
   
  
  Auricularia auricular, Lyophyllum decastes
  CSDB ID 42495 (all data & tools)