Ethyl acetate extracts of Armillaria tabescens (strain JNB-OZ344) showed significant fungistatic and bacteristatic activities against several major human pathogens including Candida albicans, Cryptococcus neoformans, Escherichia coli and Mycobacterium intracellulare. Chemical analysis of these extracts led to the isolation and identification of four new compounds, emestrin-F (1), emestrin-G (2), 6-O-(4-O-methyl-β-D-glucopyranosyl)-8-hydroxy-2,7-dimethyl-4H-benzopyran-4-one (3) and cephalosporolide-J (4), along with five other previously known compounds, emestrin (5), cephalosporolide-E (6), decarestrictine-C2 (7), ergosterol and brassicasterol. Structural elucidation of all compounds was carried out by NMR and MS analyses. Antimicrobial assays revealed that compounds 1 and 5 were responsible for the observed growth inhibitory activities of the fungal extracts against the human pathogens tested.

antimicrobial activity, Armillaria tabescens, emestrin, chromone, cephalosporolide

• Compound ID: 20486
  

  b-D-Glcp4Me-(1-6)-Subst Subst = 8-hydroxy-2,7-dimethyl-4H-benzopyran-4-one = SMILES OC1=C2C(C(C=C(C)O2)=O)=C{6}C(O)=C1C

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  Structure type: monomer ; 383.0983 [M+H]+
  C18H22O9
  Compound class: phenolic glycoside
  
   
  
  Armillaria tabescens JNB-OZ344
  CSDB ID 45040 (all data & tools)