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1. (Article ID: 8288)
Kim DC, Quang TH, Ngan NTT, Yoon CS, Sohn JH, Yim JH, Feng Y, Che Y, Kim YC, Oh H
Dihydroisocoumarin derivatives from marine-derived fungal isolates and their anti-inflammatory effects in lipopolysaccharide-induced BV2 microglia
Journal of Natural Products 78(12) (2015)
2948-2955
Chemical investigation of the EtOAc extracts of marine-derived fungal isolates Aspergillus sp. SF-5974 and Aspergillus sp. SF-5976 yielded a new dihydroisocoumarin derivative (1) and 12 known metabolites. The structures of the isolated metabolites were established by extensive spectroscopic analyses, including 1D and 2D NMR spectra and MS data. Among the metabolites, the absolute configuration of 5′-hydroxyasperentin (6) was determined by single-crystal X-ray diffraction analysis. The in vitro antineuroinflammatory effects of the metabolites were also evaluated in lipopolysaccharide (LPS)- stimulated microglial cells. Among the isolated metabolites, dihydroisocoumarin derivatives 1−6 (10−80 μM) were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively, in LPS-stimulated BV2 microglia. Further, 1 (20−80 μM) was found to suppress the phosphorylation of the inhibitor of nuclear factor kappa B-α (IκB-α), interrupt the nuclear translocation of nuclear factor kappa B (NF-κB), and decrease the activation of p38 mitogen-activated protein kinase (MAPK)
Aspergillus, antiinflammatory activity, dihydroisocoumarin glycosides
NCBI PubMed ID: 26651366Publication DOI: 10.1021/acs.jnatprod.5b00614Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: Kim YC
wku.ac.kr>; Oh H wonkwang.ac.kr>
Institutions: Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, Korea, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam, College of Medical and Life Sciences, Silla University, Busan, Korea, Korea Polar Research Institute, KORDI, Yeonsu-gu, Korea, Beijing Ditan Hospital, Capital Medical University, Beijing, China, Beijing Institute of Pharmacology & Toxicology, Beijing, China
Methods: 13C NMR, 1H NMR, NMR-2D, X-ray, DNA techniques, ELISA, Western blotting, biological assays, HPLC, extraction, optical rotation measurement, CC, cell growth, RNA sequencing, HR-ESI-MS, determination of NO production, cell viability assay
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2. (Article ID: 8881)
Li T, Wang N, Zhang T, Zhang B, Sajeevan TP, Joseph V, Armstrong L, He S, Yan X, Naman CB
A systematic review of recently reported marine derived natural product kinase inhibitors
Marine Drugs 17(9) (2019)
ID 493
Protein kinases are validated drug targets for a number of therapeutic areas, as kinase deregulation is known to play an essential role in many disease states. Many investigated protein kinase inhibitors are natural product small molecules or their derivatives. Many marine-derived natural products from various marine sources, such as bacteria and cyanobacteria, fungi, animals, algae, soft corals, sponges, etc. have been found to have potent kinase inhibitory activity, or desirable pharmacophores for further development. This review covers the new compounds reported from the beginning of 2014 through the middle of 2019 as having been isolated from marine organisms and having potential therapeutic applications due to kinase inhibitory and associated bioactivities. Moreover, some existing clinical drugs based on marine-derived natural product scaffolds are also discussed.
drug development, kinase inhibitors, marine natural products
NCBI PubMed ID: 31450856Publication DOI: 10.3390/md17090493Journal NLM ID: 101213729Publisher: Basel, Switzerland: Molecular Diversity Preservation International
Correspondence: Zhang B
126.com>; Naman CB nbu.edu.cn>
Institutions: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, USA, Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, China, Institute of Drug Discovery Technology, Ningbo University, Ningbo, China, National Centre for Aquatic Animal Health, Cochin University of Science and Technology, Kochi, India, Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil
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