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1. (Article ID: 8296)
 
Harms H, Kehraus S, Nesaei-Mosaferan D, Hufendieck P, Meijer L, Konig GM
Aβ-42 lowering agents from the marine-derived fungus Dichotomomyces cejpii
Steroids 104 (2015) 182-188
 

The ascomycete Dichotomomyces cejpii was isolated from the marine sponge Callyspongia cf. C. flammea. Three new steroids (1-3), two of which are present as glycosides, with an untypical pattern of carbon-carbon double bounds, were obtained from fungal extracts, as well as the known xanthocillin X dimethyl ether (4). Compounds 2 and 4 were evaluated in an Alzheimer's disease cellular assay and found capable of preventing the enhanced production of amyloid β-42 in Aftin-5 treated cells. Aβ-42 lowering agents are considered as candidates for the treatment of neurodegenerative Alzheimer's disease

ergosterol derivatives, Dichotomomyces cejpii, Alzheimer’s disease

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