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1. (Article ID: 8317)
Suga T, Asami Y, Hashimoto S, Nonaka K, Iwatsuki M, Nakashima T, Sugahara R, Shiotsuki T, Yamamoto T, Shinohara Y, Ichimaru N, Murai M, Miyoshi H, Omura S, Shiomi K
Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae
The Journal of Antibiotics 68(10) (2015)
649-652
A mitochondrial respiration inhibitor 1 was isolated from the fungus Aspergillus sp., (strain FKI-6682) and its structure was elucidated to be a lanostane-type triterpenoid. Our data demonstrate that 1 inhibited the mitochondrial respiratory system in yeast, particularly yeast grown in glycerol medium.
Aspergillus, Saccharomyces cerevisiae, fungicidal activity, ascosteroside C
NCBI PubMed ID: 25944534Publication DOI: 10.1038/ja.2015.43Journal NLM ID: 0151115Publisher: London: Nature Publishing Group
Correspondence: Shiomi K
lisci.kitasato-u.ac.jp>; Ōmura S insti.kitasato-u.ac.jp>
Institutions: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan, Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan, Department of Drug Discovery Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan, Department of Chemistry, School of Science, Kitasato University, Kanagawa, Japan, Research Organization for Infection Control Sciences, Kitasato University, Tokyo, Japan, Insect Growth Regulation Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Japan, Institute for Genome Research, University of Tokushima, Tokushima, Japan
Methods: 13C NMR, 1H NMR, NMR-2D, IR, TLC, ESI-MS/MS, biological assays, HPLC, UV, extraction, optical rotation measurement, CC, cell growth, HR-ESI-MS, cytotoxicity assay
The publication contains the following compound(s):
- Compound ID: 19884
|
a-D-Glcp4Me-(1-3)-Subst
Subst = ascosteroside C aglycon = SMILES C=C(CC[C@@H](C)[C@H]1C{15}[C@@H](O)[C@@]2({30}C(=O)O)/C4=C(CC[C@]12C)/[C@@]3(C)CC{3}[C@H](O)C(=C)[C@@H]3CC4)C(C)C |
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Structure type: monomer
Trivial name: ascosteroside A
Compound class: glycan, glycoside, triterpenoid glycoside
- Compound ID: 20826
|
a-D-Glcp-(1-3)-Subst
Subst = ascosteroside C aglycon = SMILES C=C(CC[C@@H](C)[C@H]1C{15}[C@@H](O)[C@@]2({30}C(=O)O)/C4=C(CC[C@]12C)/[C@@]3(C)CC{3}[C@H](O)C(=C)[C@@H]3CC4)C(C)C |
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Structure type: monomer
; 650.4249 [M+NH4]+
C36H56O9
Trivial name: ascosteroside C
Compound class: glycoside, triterpenoid glycoside
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