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1. (Article ID: 8431)
Manna DK, Nandi AK, Pattanayak M, Maity P, Tripathy S, Mandal AK, Roy S, Tripathy SS, Gupta N, Islam SS
A water soluble β-glucan of an edible mushroom Termitomyces heimii: Structural and biological investigation
Carbohydrate Polymers 134 (2015)
375-384
A water soluble β-glucan (PS-I) with an average molecular weight 148000 Da was isolated from the alkaline extract of an edible mushroom Termitomyces heimii. PS-I contained (1→3)-, (1→6)-, (1→3,6)-linked and terminal β-D-glucopyranosyl moieties in a ratio of nearly 2:1:1:1. Based on the total hydrolysis, methylation analysis, periodate oxidation, Smith degradation, partial hydrolysis and 1D/2D NMR experiments the structure of the PS-I was elucidated. On the basis of these experiments, the repeating unit of the polysaccharide was found to consist of a backbone chain of two (1→6)-β-D-glucopyranosyl residues, one of which was branched at O-3 position with the side chain consisting of two (1→3)-β-D-glucopyranosyl and a terminal β-D-glucopyranosyl residue. Cytotoxic effect of PS-I on human blood lymphocytes at varied concentrations was studied. Moreover, it also exhibited potent antioxidant activities by diminishing the ROS and NO in the nicotine stimulated lymphocytes up to 200 μg/ml
β-glucan, biological properties, NMR studies, Termitomyces heimii
NCBI PubMed ID: 26428137Publication DOI: 10.1016/j.carbpol.2015.07.099Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: Islam SS
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Institutions: Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore, India, Department of Microbiology, Vidyasagar University, Midnapore, India, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore, India, Division of Plant Pathology and Microbiology, Regional Plant Resource Centre, Bhubaneswar, India
Methods: 13C NMR, 1H NMR, methylation, periodate oxidation, NMR-2D, GC-MS, acid hydrolysis, GC, Smith degradation, biological assays, GPC, UV, extraction, optical rotation measurement, acetylation, reduction, determination of NO production, cell viability assay, phenol-sulfuric acid assay, derivatization, Gerwig method
The publication contains the following compound(s):
- Compound ID: 21051
Structure type: oligomer
Reference(s) to other database(s): GTC:G14492VN
- Compound ID: 21052
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b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-+
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-6)-b-D-Glcp-(1-6)-b-D-Glcp-(1- |
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Structure type: polymer chemical repeating unit
; 148000
Compound class: glucan, polysaccharide
Reference(s) to other database(s): GTC:G36024OR
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