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1. (Article ID: 8496)
 
Niu YC, Liu JC, Zhao XM, Su FQ, Cui HX
Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice
Die Pharmazie 64(7) (2009) 472-476
 

LMPAB is a linear β-(1-3)-glucan we isolated from polysaccharide extract of Agaricus blazei Murill (AbM). Effects of LMPAB on splenic natural killer (NK) cell activity, splenocyte proliferation, index of spleen and thymus, IFN-gamma expression in spleen and the concentration of IL-12, IL-18 and TNF-α in serum of S180 ascitic tumor-bearing mice were detected. The results showed that intraperitoneal injection of LMPAB (100 mg/kg/d) significantly increased the thymus index. LMPAB augmented splenic NK cell activity in a dose-dependent manner (50-200 mg/kg/d). The concanavalin A (3 microg/ ml) stimulated splenocyte proliferation was significantly enhanced by LMPAB at dosages of 50, 100 or 200 mg/kg/d. Further studies showed that LMPAB (50, 100 or 200 mg/kg/d, 14d) significantly increased the production of IL-12, TNF-α, IL-18 and the expression IFN-gamma as determined by ELISA and immunohistochemistry, respectively. These results clearly indicate that the anti-tumor effects of LMPAB are closely associated with up-regulation of activity of NK cells, expression of IFN-gamma in spleen and the systemic level of IL-12, IL-18 and TNF-α in tumor-bearing mice

mice, sarcoma 180, Immunostimulatory activity, Agaricus blazei, β-(1-3)-glucan

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