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1. (Article ID: 8616)
Luo Q, Yan L, Xu P, Xiong C, Yang Z, Hu P, Hu H, Hong R
Discovery of a polysaccharide from the fruiting bodies of Lepista sordida as potent inhibitors of indoleamine 2, 3-dioxygenase (IDO) in HepG2 cells via blocking of STAT1-mediated JAK-PKC-δ signaling pathways
Carbohydrate Polymers 197 (2018)
540-547
The present study examined the role of a polysaccharide (LSP, 25 and 100 μg/ml) from the fruiting bodies of Lepista sordid on the immunosuppressive enzyme indoleamine 2, 3-dioxygenase (IDO) in HepG2 cells, and the possible mechanism of action. IDO expression and kynurenine production from LSP-treated HepG2 cells following IFN-γ stimulation were dramatically inhibited by LSP treatment. In line with this, the medium of HepG2 cells pretreated with LSP improved the survival rate of primary CD4+ and CD8+ T cells as compared with IFN-γ-treated control cells. Moreover, tyrosine 701 and serine 727 phosphorylation of STAT1 were dramatically reduced by LSP pretreatment in IFN-γ-stimulated HepG2 cells. Furthermore phosphorylation of JAK-1 and JAK-2 was also inhibited by LSP. Additionally, two IDO promoters (GAS and ISRE) were inhibited in cells pretreated with LSP prior to IFN-γ exposure. These findings suggest that LSP exerts antitumor effects on HepG2 cells by inhibiting IDO via JAK-PKC-δ-STAT1 signaling pathway.
hepatocellular carcinoma (HCC), IFN-γ, indoleamine 2, 3-dioxygenase (IDO), JAK-PKC-δ-STAT1 signaling pathway, Lepista sordid polysaccharide
NCBI PubMed ID: 30007645Publication DOI: 10.1016/j.carbpol.2018.05.052Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: Hong R
yahoo.com>
Institutions: Sichuan Province Key Laboratory of Nature Resources Microbiology and Technique, College of Life Sciences, Sichuan University, Chengdu, China, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Chinese Ministry of Education, Department of Infectious Diseases, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China, Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China, Biotechnology and Nuclear Technology Research Institute, Sichuan Academy of Agricultural Sciences, Chengdu, China
Methods: PCR, Western blotting, statistical analysis, luciferase assays, confocal microscopy, cytotoxicity assay, MTT
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2. (Article ID: 8704)
Oleinikova GK, Denisenko VA, Berdyshev DV, Pushilin MA, Kirichuk NN, Menzorova NI, Kuzmich AS, Yurchenko EA, Zhuravleva OI, Afiyatullov SS
Two new sesterterpenoids, terretonins H and I, from the marine-derived fungus Aspergillus ustus
Phytochemistry Letters 17 (2016)
135-139
Two new sesterterpenoids, terretonins H(1) and I(2), together with two known compounds, strobilactone A(3) and cerebroside D(4), were isolated from the lipophilic extract of the marine-derived fungus Aspergillus ustus KMM 4664. The structures of compounds 1 and 2 were determined based on spectroscopic methods and confirmed by X-ray crystallographic analysis of terretonin H. All compounds were tested for cytotoxic and embryotoxic effects using sperm and developing embryos of the sea urchin Strongylocentrotus intermedius and human cancer cells.
terretonin, sesterterpenoids, Aspergillus ustus, Strongylocentrotus intermedius
Publication DOI: 10.1016/j.phytol.2016.07.002Journal NLM ID: 101513432Publisher: Amsterdam: Elsevier
Correspondence: Afiyatullov SS
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Institutions: Far Eastern Federal University, Vladivostok, Russia, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia, Institute of Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia
The publication contains the following compound(s):
- Compound ID: 18694
Structure type: monomer
C43H81O9N
Trivial name: cerebroside C, cerebroside D
Compound class: glycolipid, glycosphingolipid, glycoside, cerebroside, ceramide
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3. (Article ID: 11423)
Kisiel W, Janeczko Z, Zgud-Walaszek M
A germacradiene glycoside from roots of Pimpinella saxifraga
Phytochemistry 49(7) (1998)
2031-2033
A new germacradiene glycoside was found to occur in the roots of Pimpinella saxifraga. The structure of its acetylation product was determined by spectroscopic methods, including 2D NMR techniques.
glycoside, sesquiterpene, Umbelliferae, Pimpinella saxifraga, germacradiene
Publication DOI: 10.1016/S0031-9422(98)00399-9Journal NLM ID: 0151434Publisher: Elsevier
Institutions: Department of Phytochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland, Department of Pharmacognosy, Pharmaceutical Faculty of the Collegium Medicum, Jagiellonian University, Krakow, Poland
Methods: 13C NMR, 1H NMR, EI-MS, IR, TLC, UV, CC, melting point determination, extractin
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