Found 1 publication.
Displayed publication 1
Expand all publications
Collapse all publications
Show all as text (SweetDB notation)
Show all graphically (SNFG notation)
1. (Article ID: 8625)
Penso J, Cordeiro KC, da Cunha CR, da Silva Castro PF, Martins DR, Lião LM, Rocha ML, de Oliveira V
Vasorelaxant activity of 7-β-O-glycosides biosynthesized from flavonoids
European Journal of Pharmacology 733 (2014)
75-80
In this work we report the vasorelaxant activity of 7-β-O-glycosides obtained with biosynthesis of naringenin-7-β-O-glycoside (3) and quercetin-7-β-O-glycoside (4). These compounds were obtained from naringenin (1) and quercetin (2) glycosylation catalyzed by Beauveria bassiana ATCC 7159. Screening of the best strain as a catalyst for glycosylation was carried out and the reaction conditions established. Cultures were grown in PDSM medium for 7 days at 27 °C. After purification by reverse-phase preparative HPLC, naringenin-7-β-O-glycoside (3) and quercetin-7-β-O-glycoside (4) were identified by (1)H and (13)C NMR. The right position and β-configuration of the glucose was determined through HSQC and HMBC experiments. The vasorelaxation potential of naringenin, quercetin and its glycosylated derivatives was evaluated using isolated aorta in vitro models. Interestingly, results suggest that vasorelaxation properties of naringenin, rutin and its glycosides are due to different pathways.
glycosylation, quercetin, Beauveria bassiana, aorta relaxation, naringenin
NCBI PubMed ID: 24704375Publication DOI: 10.1016/j.ejphar.2014.03.014Journal NLM ID: 1254354Publisher: Amsterdam: Elsevier
Correspondence: de Oliveira V
ufg.br>
Institutions: Laboratório de Ressonância Magnética Nuclear, Instituto de Química, Universidade Federal de Goiás, Campus Samambaia, Goiânia, Brazil, Laboratório de Bioconversão, Faculdade de Farmácia, Universidad eFederal de Goiás, Setor Universitário,Brazil, Laboratório de Farmacologia Cardiovascular, Faculdade de Farmácia, Universidade Federal de Goiás, Setor Universitário, Brazil
Methods: 13C NMR, 1H NMR, HMBC, HPLC-UV, biological studies
The publication contains the following compound(s):
- Compound ID: 21247
Structure type: monomer
Trivial name: quercimeritrin
Compound class: glucoside, glycoside, flavonoid glycoside
Reference(s) to other database(s): PubChem: 5282160
- Compound ID: 21410
|
b-D-Glcp-(1-7)-Subst
Subst = naringenin = SMILES O=C1CC(C2=CC={54}C(O)C=C2)OC3=C{7}C(O)={6}C{5}C(O)=C13 |
Show graphically |
Structure type: monomer
Trivial name: prunin
Compound class: glycoside, flavonoid glycoside
Expand this publication
Collapse this publication
Total list of publication IDs on all result pages of the current query:
Total list of corresponding CSDB IDs (permanent record IDs):
Execution: 1 sec