One of the most commonly consumed mushrooms in Europe is Cantharellus cibarius, also known as chanterelles. Therefore, the investigation of the pro-health properties of crude polysaccharides from this species was performed. The obtained results indicate that the polysaccharide fraction from C. cibarius inhibits the activity of both COX-1 and COX-2. Moreover, the prebiotic potential was revealed in relation to Lactobacillus strains. Crude polysaccharides were found to inhibit the proliferation of colon cancer cells with the simultaneous absence of toxicity towards normal cells. The purification and structural characterization of the examined polysaccharide fraction from C. cibarius indicates that it consists of one monosaccharide in the repeating unit →6)-α-D-Manp-(1→. The presented activities indicate for the first time that this edible mushroom possesses interesting chemopreventive potential, especially against colon cancer.

Colon cancer, prebiotic, Anticancer, anti-inflammatory, Edible mushroom, chemoprevention

• Compound ID: 2167
  

  -6)-a-D-Manp-(1-

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  Structure type: homopolymer
  Trivial name: LAM, mannan, galactomannan, cell wall heteromannan
  Compound class: EPS, O-polysaccharide, cell wall polysaccharide, N-glycan, cell surface polysaccharide, mannan, D-mannan, galactomannan
  Reference(s) to other database(s): GTC:G55317BB, GlycomeDB:6776, CCSD:46066, CBank-STR:6345
  
   
  
  Cantharellus cibarius
  CSDB ID 49053 (all data & tools)