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1. (Article ID: 8818)
Wu YN, Chen Y, Huang XS, Pan YH, Liu ZM, Yan T, Cao WH, She ZG
α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3
Marine Drugs 16(9) (2018)
ID: 307 (1-9)
Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3-6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the province of Guangdong, China. The structures of compounds 1-6 were determined by analyzing NMR and HRESIMS data. The absolute configurations of 5 and 6 were assigned by comparing their experimental ECD spectra with those reported for similar compounds in the literature. All isolates were evaluated for their -glucosidase inhibitory activity, of which compounds 3, 5, 10, and 11 showed strong inhibitory effects with IC50 values in the range of 1.5-4.5 M.
mangrove endophytic fungus, Aspergillus flavus, α-glucosidase inhibitors
NCBI PubMed ID: 30200400Publication DOI: 10.3390/md16090307Journal NLM ID: 101213729Publisher: Basel, Switzerland: Molecular Diversity Preservation International
Correspondence: Wu YN
mail2.sysu.edu.cn>; Huang XS mail.sysu.edu.cn>; Pan YH 126.com>; Chen Y mail2.sysu.edu.cn>; Yan T scsio.ac.cn>; Cao WH 163.com>; Liu ZM mail2.sysu.edu.cn>; She ZG mail.sysu.edu.cn>
Institutions: School of Chemistry, Sun Yat-Sen University, Guangzhou, China, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, School of Marine Sciences, Sun Yat-Sen University, Guangzhou, China, State Key Laboratory of Applied Microbiology, Southern China, Guangdong Institute of Microbiology, Guangzhou, China, CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China
Methods: IR, HPLC, UV, extraction, HR-ESI-MS, inhibition assay, optical rotation measurements, TLs
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