Endophytic fungi have been known as potential sources of bioactive metabolites with promising application in medicine and agriculture. A research had been undertaken to determine the profile of chemical compounds of endophytic fungi from mature anona leaves (Annona squamosa L.) growing in hot and dry area in Timor Island. The purpose of this study was to isolate endophytic fungi from mature anona leaves, to determine the content of chemical compounds using HPLC and LC-MS/MS and to evaluate its antibacterial activity. In this study, an endophytic fungus from mature anona leaves was isolated and identified as Aspergillus niger. The endophytic fungi was then grown on solid rice media and extracted with ethyl acetate. The HPLC analysis of ethyl acetate extract showed the presence of active compounds. Further analysis of LC-MS/MS showed that there were five compounds including Lycorine compounds, Fuzinoside, Neoline-1, Trichosanic acid and Ergosta-4,6,8(14),22-tetraen-3-one. The antibacterial activity test showed that ethyl acetate extract of endophytic fungi Aspergillus niger had intermediate properties against Staphyloccus aureus, Escherechia coli and Salmonella enteritidis with diameter of zone inhibition of 10.4, 10.0 and 11.0 mm, respectively.
antibacterial activity, metabolites, Aspergillus niger, endophytic fungi, Annona squamosa
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