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1. (Article ID: 9191)
 
Teng LL, Song TY, Chen YH, Chen YG, Zhang KQ, Li SH, Niu XM
Novel polyketide-terpenoid hybrid metabolites from a potent nematicidal Arthrobotrys oligospora mutant ΔAOL_s00215g278
Journal of Agricultural and Food Chemistry 68(41) (2020) 11449-11458
 

Here, we reported that detailed investigation on trace targeted metabolites from nematode-trapping fungus Arthrobotrys oligospora mutant with deletion of P450 gene AOL_s00215g278 led to isolation of 9 new polyketide-terpenoid hybrid derivatives, including four new glycosides of the key precursor farnesyl hydrotoluquinol (1) and, surprisingly, four new sesquiterpenyl epoxy-cyclohexenoids (SECs) analogues. Among them, two major target metabolites 1 and 14 displayed moderate nematode inhibitory ability. Moreover, the mutant lacking AOL_s00215g278 could form far more nematode-capturing traps within 6 h in contact with nematodes and show rapid potent nematicidal activity with killing 93.7% preys, though deletion of the P450 gene resulted in dramatic decrease in fungal colony growth and failure to produce fungal conidia. The results unequivocally revealed that gene AOL_s00215g278 should be involved in not only the SEC biosynthetic pathway in the nematode-trapping fungus A. oligospora but also fungal conidiation and nematicidal activity.

biosynthesis, Arthrobotrys oligospora, arthrosporols, nematode-trapping fungus, terpenyl epoxycyclohexone, trap formation, P450 gene AOL_s00215g278

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