Found 1 structure.
Displayed structure 1
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1. Compound ID: 9197
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Lau-(1-3)-3HOMyr-(1-2)-+
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3HOLau-(1-3)-+ |
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EtN-(1---P---P---4)-+ | |
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a-D-GlcpNAc-(1-2)-+ | | |
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EtN-(1--P--3)--L-gro-a-D-manHepp-(1-3)-+ a-Kdop-(2-4)-+ | | |
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-b-D-GlcpN-(1-P
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Lau-(1-3)-3HOMyr-(1-2)-+ 3HOLau-(1-3)-+ |
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Structure type: oligomer
Compound class: LPS
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130646,IEDB_130650,IEDB_130659,IEDB_130697,IEDB_135515,IEDB_135813,IEDB_136044,IEDB_136106,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391966,IEDB_140087,IEDB_140088,IEDB_140089,IEDB_140090,IEDB_140108,IEDB_140110,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142351,IEDB_142487,IEDB_142488,IEDB_146100,IEDB_146664,IEDB_149144,IEDB_149174,IEDB_150933,IEDB_151531,IEDB_175430,IEDB_190606,IEDB_2189047,IEDB_226300,IEDB_418761,IEDB_418762,IEDB_418763,IEDB_418764,IEDB_418765,IEDB_418766,IEDB_418767,IEDB_418768,IEDB_418769,IEDB_418770,IEDB_419428,IEDB_419429,IEDB_423120,IEDB_534864,IEDB_983931,SB_115,SB_116,SB_131,SB_145,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_187,SB_192,SB_195,SB_30,SB_39,SB_6,SB_68,SB_7,SB_84,SB_88
The structure is contained in the following publication(s):
- Article ID: 3940
Schielke S, Schmitt C, Spatz C, Frosch M, Schubert-Unkmeir A, Kurzai O "The transcriptional repressor FarR is not involved in meningococcal fatty acid resistance mediated by the FarAB efflux pump and dependent on LPS structure" -
Applied and Environmental Microbiology 76(10) (2010) 316-6169
Free fatty acids are important antimicrobial substances regulating the homeostasis of colonizing bacteria on epithelial surfaces. Here we show that meningococci express a functional farAB efflux pump, which is indispensable for fatty acid resistance. However - other than in Neisseria gonorrhoeae - the transcriptional regulator NmFarR is not involved in regulation of this operon in N. meningitidis. We tested the susceptibility of 23 meningococcal isolates against saturated and unsaturated long chain fatty acids, proving that meningococci are generally highly resistant, with exception of serogroup Y strains belonging to sequence type 23. Using genetically determined lipopolysaccharide (LPS) truncated mutant strains we show that addition of the LPS core oligosaccharide and hexa-acylation of its membrane-anchor lipid A are imperative for fatty acid resistance of meningococci. The sensitivity of the serogroup Y strains is due to naturally occurring mutations within the lpxL1 gene, which is responsible for addition of the sixth acyl chain on the LPS membrane-anchor lipid A. Therefore fatty acid resistance in meningococci is provided by both the active efflux pump FarAB and by the natural permeability barrier of the Gram-negative outer membrane. The transcriptional regulator FarR is not implicated with fatty acid resistance in meningococci, possibly causing a constitutively active FarAB efflux pump system and thus revealing diverse mechanisms of niche adaptation in the two closely related Neisseria species.
Neisseria meningitidis, Bacterial Proteins, Bacterial, fatty acids, drug resistance
NCBI PubMed ID: 20348314Publication DOI: 10.1128/AEM.02833-09Journal NLM ID: 7605801Publisher: American Society for Microbiology
Correspondence: oliver.kurzai@hki-jena.de
Institutions: University of Wurzburg, Germany, Institute of Hygiene and Microbiology, Wurzburg, Germany, Friedrich Schiller University Jena, Septomics Research Centre, Jena, Germany
Methods: genetic methods
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