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1. (Article ID: 9198)
Kubo I, Yokokawa Y
Two tyrosinase inhibiting flavonol glycosides from Buddleia coriacea
Phytochemistry 31(3) (1992)
1075-1077
Two new flavonol glycosides, buddlenoids A and B, have been isolated and identified as tyrosinase inhibitors from the aerial parts of Buddleia coriacea. Their structures were deduced from spectroscopic evidence to be kaempferol 7-(6″-p-coumaroylglucoside) and isorhamnetin 7-(6″-p-coumaroylglucoside). Both buddlenoids showed high inhibition of mushroom tyrosinase.
Buddleia coriacea, Loganiaceae, flavonol glucoside, buddlenoid A, buddlenoid B, tyrosinase inhibitory activity
Publication DOI: 10.1016/0031-9422(92)80084-RJournal NLM ID: 0151434Publisher: Elsevier
Institutions: Division of Entomology and Parasitology, College of Natural Resources, University of California, Berkeley, USA
Methods: 13C NMR, 1H NMR, FAB-MS, inhibition studies, extraction, CC, melting point determination, enzymatic assay
The publication contains the following compound(s):
- Compound ID: 22435
|
Subst-(9-6)-b-D-Glcp-(1-7)-Kaempferol
Subst = (E)-3-(4-hydroxyphenyl)acrylic acid, trans-p-coumaric acid = SMILES O={9}C(O)/C=C/c1cc{4}c(O)cc1 |
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Structure type: monomer
; 593 [M-H]-
C30H26O13
Trivial name: buddlenoid A
Compound class: glycoside, flavonoid glycoside
- Compound ID: 22436
|
Subst-(9-6)-b-D-Glcp-(1-7)-Subst1
Subst = (E)-3-(4-hydroxyphenyl)acrylic acid, trans-p-coumaric acid = SMILES O={9}C(O)/C=C/c1cc{4}c(O)cc1;
Subst1 = isorhamnetin = SMILES O{3}C1=C(C2=CC={54}C(O)C(OC)=C2)OC3=C({5}C(O)=C{7}C(O)=C3)C1=O |
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Structure type: monomer
; 623 [M-H]-
C31H28O14
Trivial name: buddlenoid B
Compound class: glycoside, flavonoid glycoside
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2. (Article ID: 9199)
Kubo I, Yokokawa Y, Kinst-Hori I
Tyrosinase inhibitors from Bolivian medicinal plants
Journal of Natural Products 58(5) (1995)
739-743
Bioassay-guided fractionation monitored by mushroom tyrosinase (EC 1.14.18.1) activity, afforded six inhibitors from three Bolivian medicinal plants, Buddleia coriacea, Gnaphalium cheiranthifolium, and Scheelea princeps. These inhibitors, which are all known phenolic compounds, inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) mediated by a mushroom tyrosinase.
Buddleia coriacea, Loganiaceae, flavonol glucoside, buddlenoid A, buddlenoid B, tyrosinase inhibitory activity
NCBI PubMed ID: 7623048Publication DOI: 10.1021/np50119a013Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Institutions: Division of Entomology and Parasitology, College of Natural Resources, University of California, Berkeley, USA
Methods: 13C NMR, 1H NMR, FAB-MS, inhibition studies, HPLC, extraction, CC, reversed-phase chromatography, enzymatic assay
The publication contains the following compound(s):
- Compound ID: 22437
|
Subst-(9-6)-b-D-Glcp-(1-7)-Kaempferol
Subst = (E)-3-(4-hydroxyphenyl)acrylic acid, trans-p-coumaric acid = SMILES O={9}C(O)/C=C/c1cc{4}c(O)cc1 |
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Structure type: monomer
Trivial name: buddlenoid A
Compound class: glycoside, flavonoid glycoside
- Compound ID: 22438
|
Subst-(9-6)-b-D-Glcp-(1-7)-Subst1
Subst = (E)-3-(4-hydroxyphenyl)acrylic acid, trans-p-coumaric acid = SMILES O={9}C(O)/C=C/c1cc{4}c(O)cc1;
Subst1 = isorhamnetin = SMILES O{3}C1=C(C2=CC={54}C(O)C(OC)=C2)OC3=C({5}C(O)=C{7}C(O)=C3)C1=O |
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Structure type: monomer
Trivial name: buddlenoid B
Compound class: glycoside, flavonoid glycoside
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