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1. (Article ID: 9267)
 
Krylov VB, Nifantiev NE
Synthetic carbohydrate based anti-fungal vaccines
Drug Discovery Today: Technologies (2020) 35-43
 

Emerging growth of antimycotic resistance among fungal pathogens stimulates the development of corresponding vaccines and therapeutic monoclonal antibodies for active and passive immunization. The polysaccharide components of the fungal cell wall which are not present in humans and mammalians are regarded as promising targets for development of antifungal immunotherapy. Unfortunately, purified fungal antigens related to cell wall polysaccharides are not easily available from natural sources. Moreover, most of these polysaccharides are extremely heterogenic, comprised of different antigenic factors exhibiting different immunogenic properties. Today, the design of efficient antifungal vaccines requires a reliable alternative for such polymers, challenging the synthesis of complex oligosaccharide structures related to polysaccharide antigens. Special attention should be paid to the selection of the target epitope to ensure the protective properties of the vaccine. This review discusses the potential of fungal cell-wall polysaccharides as the basis for development glycoconjugate vaccines on the basis of synthetic oligosaccharides and summarizing contemporary challenges in this field.

synthesis, vaccine, Candida albicans, Cryptococcus neoformans, fungal oligosaccharides

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