Two new cerebrosides, asperiamide B (1) and C (2), and two known aflatoxins, averufin and nidurufin, have been isolated from a Quanzhou marine fungus Aspergillus niger (MF-16), and the structures were elucidated by spectroscopic data and chemical means. Among the compounds 5 and 6 showed moderate activities in inhibiting multiplication of the Tobacco Mosaic Virus (TMV).

anthraquinone, cerebroside, Aspergillus niger, Marine fungus, asperiamide B, asperiamide C

Publication DOI: 10.1002/cjoc.200890142
Journal NLM ID: 101312673
Publisher: Beijing, China: Science Press
Correspondence: maouyangyahoo.com
Institutions: Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, China, Education Ministry, Key Laboratory of Bio-pesticide and Chemistry-Biology, Fujian Agriculture and Forestry University, Fuzhou, China, Department of Chemistry, National Taiwan University, Taipei, China
Methods: 13C NMR, 1H NMR, IR, FAB-MS, TLC, ELISA, acid hydrolysis, biological assays, UV, extraction, optical rotation measurement, HPTLC, CC, cell growth, evaporation, HR-FAB-MS
 

• Compound ID: 22736
  

  Subst-(1-2)-+ | b-D-Glcp-(1-1)-Subst1 Subst = 2R-hydroxytrideca-3E,5E,7E,9E-tetraenoic acid = SMILES CCC/C=C/C=C/C=C/C=C/{2}[C@@H](O){1}C(O)=O; Subst1 = (2R,3S)-sphinganine-C23 = SMILES O{1}C{2}[C@@H](N){3}[C@H](O)CCCCCCCCCCCCCCCCCCCC

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  Structure type: monomer ; 736.5363 [M-H]-
  C42H75NO9
  Trivial name: asperiamide B
  Compound class: glycolipid, cerebroside
  
   
  
  Aspergillus niger MF-16
  CSDB ID 51133 (all data & tools)
• Compound ID: 22737
  

  b-D-Glcp-(1-1)-+ | R-2HOC16={t3}-(1-2)-Subst Subst = (2S,4E,8E)-2-amino-9-methyltricosa-4,8-diene-1,3-diol = SMILES CCCCCCCCCCCCCC/C(C)=C/CC/C=C/{3}C(O){2}[C@@H](N){1}CO

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  Structure type: monomer ; 780.5989 [M-H]-
  C45H83NO9
  Trivial name: asperiamide C
  Compound class: glycolipid, cerebroside
  
   
  
  Aspergillus niger MF-16
  CSDB ID 51134 (all data & tools)