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1. (Article ID: 9415)
Chi L-P, Li X-M, Wan Y-P, Li Y-H, Li X, Wang B-G
Two new phenol derivatives from the cold seep-derived fungus Aspergillus insuetus SD-512
Chemistry and Biodiversity 18(10) (2021)
ID e2100512
Two new phenol derivatives, namely insphenol A (1) and acetylpeniciphenol (2), along with seven known analogs (3-9), were isolated from the deep-sea cold seep-derived fungus, Aspergillus insuetus SD-512. The structures of 1 and 2 were established by extensive interpretation of NMR and mass spectroscopic data. The absolute configuration of 1 was determined by the combination of coupling constant analysis and acid hydrolysis. Among the isolated compounds, insphenol A (1) represents the first example of isopentenyl phenol derivative with a unique 1-glycosylation from the species Aspergillus insuetus. The isolated new compounds were evaluated for antibacterial activities against six human or aquatic pathogens, while compound 2 exhibited inhibitory effect against Edwardsiella tarda, Vibrio alginolyticus, and V. vulnificus, with MIC values of 4, 8, and 8 μg/mL, respectively.
antibacterial activity, marine natural products, Aspergillus insuetus, cold seep-derived fungus
NCBI PubMed ID: 34347345Publication DOI: 10.1002/cbdv.202100512Journal NLM ID: 101197449Publisher: Verlag Helvetica Chimica Acta
Correspondence: Li X
qdio.ac.cn>; Wang B-G ms.qdio.ac.cn>
Institutions: University of Chinese Academy of Sciences, Beijing, China, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China, Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China, Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China
Methods: 13C NMR, 1H NMR, NMR-2D, IR, acid hydrolysis, HPLC, UV, extraction, optical rotation measurement, CC, HR-ESI-MS, antibacterial assay, derivatization, PTLC, VLC
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