Two new compounds, asperbenzophenone A (1) and versicolamide C (5), together with fifteen known compounds were isolated from a soft coral derived fungus Aspergillus sp. SCSIO 41036. Their structures were elucidated by spectroscopic methods, ECD analysis, and by a comparison with data from the literature. In bioassay, compound 8 showed significant inhibitory activity against lipopolysaccharide-inducted nitric oxide (NO) in RAW264.7 cells at the concentration of 10 μM. Additionally, the anti-acetylcholinesterase activity assay showed that 14 exhibited weak inhibition with an IC50 value of 157.8 μM.

nitric oxide, Aspergillus, acetylcholinesterase inhibitory, soft coral

• Compound ID: 23275
  

  Subst1-(1-2)-+ | b-D-Glcp-(1-1)-Subst Subst = (2S,3R,4E,8E)-2-amino-9-methylpentadeca-4,8-diene-1,3-diol = SMILES CCCCCC/C(C)=C/CC/C=C/{3}[C@@H](O){2}[C@@H](N){1}CO; Subst1 = 2R-hydroxynonadecanoic acid = SMILES CCCCCCCCCCCCCCCCC{2}[C@@H](O){1}C(O)=O

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  Structure type: monomer
  Trivial name: chrysogeside E
  Compound class: glucosylceramide
  
   
  
  Aspergillus sp. SCSIO 41036
  CSDB ID 51645 (all data & tools)