Found 2 structures.
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1. Compound ID: 9693
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a-L-Fucp-(1-2)-+
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-4)-b-D-Glcp-(1-3)-b-D-Galp-(1-6)-a-D-Manp-(1- |
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Structure type: polymer chemical repeating unit
Compound class: EPS, glucan
Contained glycoepitopes: IEDB_130701,IEDB_136044,IEDB_136045,IEDB_137472,IEDB_141794,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_144983,IEDB_146664,IEDB_152206,IEDB_152214,IEDB_174333,IEDB_190606,IEDB_983930,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_44,SB_67,SB_7,SB_72,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 4054
Kodali VP, Perali RS, Sen R "Purification and partial elucidation of the structure of an antioxidant carbohydrate biopolymer from the probiotic bacterium Bacillus coagulans RK-02" -
Journal of Natural Products 74(8) (2011) 1692-1697
An exopolysaccharide (EPS) was isolated from Bacillus coagulans RK-02 and purified by size exclusion chromatography. The purified, homogeneous EPS had an average molecular weight of approximately 3 x 10 Da by comparison with FITC-labeled dextran standards. In vivo evaluations showed that, like other reported polysaccharides, this EPS displayed significant antioxidant activity. FTIR spectroscopy analysis showed the presence of hydroxy, carboxy, and α-glycosidic linkages and a mannose residue. GC analysis indicated that the EPS was a heteropolymer composed of glucose, mannose, galactose, glucosamine, and fucose as monomeric constituent units. Partial elucidation of the structure of the carbohydrate biopolymer based on GC-MS and NMR analysis showed the presence of two unique sets of tetrasaccharide repeating units that have 1→3 and 1→6 glycosidic linkages. This is also the first report of a Gram-positive bacterial polysaccharide with both fucose as a sugar monomer and 1→3 and 1→6 glycosidic linkages in the molecular backbone.
exopolysaccharide, Antioxidants, Bacillus coagulans, FTIR spectroscopy
NCBI PubMed ID: 21800834Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: rksen@yahoo.com
Institutions: Department of Biotechnology, Indian Institute of Technology, Kharagpur-721302, West Bengal, India
Methods: 13C NMR, 1H NMR, methylation, GC-MS, acid hydrolysis, GC, FTIR, composition analysis
- Article ID: 5266
Wang H, Liu YM, Qi ZM, Wang SY, Liu SX, Li X, Wang HJ, Xia XC "An overview on natural polysaccharides with antioxidant properties" -
Current Medicinal Chemistry 20(23) (2013) 2899-2913
Pharmacotherapy using natural substances can be currently regarded as a very promising future alternative to conventional therapy. With the rapid development of biotechnologies and analytical techniques, a great number of methods have been developed for the identification and quantification of the material, extracts, and products of natural ingredients. The advances available today. The need for safer drugs without side effects has led to the use of natural ingredients with proven safety. In recent years, some bioactive polysaccharides isolated from natural sources have attracted much attention in the field of biochemistry and pharmacology. As an example, polysaccharides or their glycoconjugates were shown to exhibit multiple biological activities including anticarcinogenic, anticoagulant, immunostimulating, antioxidant, etc. During the last several years, we have witnessed a steady expansion in the number of publications that focus in antioxidant polysaccharides. This review presents current findings on the latest advancements and trends in antioxidant polysaccharides isolated from the following: plants, fungi, bacteria, animal sources, and algae. Some interesting studies focus on investigation of the relationship between their structure and antioxidant activity, elucidation of their antioxidant mechanism at the molecular level, and improvement of their various biological activities by chemical modifications. Although the mechanism of their antioxidant action is still not completely clear, these polysaccharides are suggested to enhance cell-mediated immune responses in vivo and in vitro and act as biological response modifiers.
polysaccharides, natural, Antioxidant, reactive oxygen species (ROS)
NCBI PubMed ID: 23627941Publication DOI: 10.2174/0929867311320230006Journal NLM ID: 9440157Publisher: Saif Zone, Sharjah, U.A.E.: Bentham Science Publishers
Correspondence: Liu YM
Institutions: Engineering and Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Gansu, China, Key Lab of New Animal Drug Project of Gansu Province, Gansu, China, Key Lab of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutics Sciences of Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China
Methods: GC-MS, NMR, HPAEC, GC, MS, FTIR, extraction, MTT
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2. Compound ID: 9694
|
a-L-Fucp-(1-6)-+
|
-4)-b-D-Glcp-(1-3)-b-D-Galp-(1-3)-a-D-GlcpN-(1- |
Show graphically |
Structure type: polymer chemical repeating unit
Compound class: EPS, glucan
Contained glycoepitopes: IEDB_136044,IEDB_136045,IEDB_137472,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_146664,IEDB_151531,IEDB_152214,IEDB_174333,IEDB_190606,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 4054
Kodali VP, Perali RS, Sen R "Purification and partial elucidation of the structure of an antioxidant carbohydrate biopolymer from the probiotic bacterium Bacillus coagulans RK-02" -
Journal of Natural Products 74(8) (2011) 1692-1697
An exopolysaccharide (EPS) was isolated from Bacillus coagulans RK-02 and purified by size exclusion chromatography. The purified, homogeneous EPS had an average molecular weight of approximately 3 x 10 Da by comparison with FITC-labeled dextran standards. In vivo evaluations showed that, like other reported polysaccharides, this EPS displayed significant antioxidant activity. FTIR spectroscopy analysis showed the presence of hydroxy, carboxy, and α-glycosidic linkages and a mannose residue. GC analysis indicated that the EPS was a heteropolymer composed of glucose, mannose, galactose, glucosamine, and fucose as monomeric constituent units. Partial elucidation of the structure of the carbohydrate biopolymer based on GC-MS and NMR analysis showed the presence of two unique sets of tetrasaccharide repeating units that have 1→3 and 1→6 glycosidic linkages. This is also the first report of a Gram-positive bacterial polysaccharide with both fucose as a sugar monomer and 1→3 and 1→6 glycosidic linkages in the molecular backbone.
exopolysaccharide, Antioxidants, Bacillus coagulans, FTIR spectroscopy
NCBI PubMed ID: 21800834Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: rksen@yahoo.com
Institutions: Department of Biotechnology, Indian Institute of Technology, Kharagpur-721302, West Bengal, India
Methods: 13C NMR, 1H NMR, methylation, GC-MS, acid hydrolysis, GC, FTIR, composition analysis
- Article ID: 5266
Wang H, Liu YM, Qi ZM, Wang SY, Liu SX, Li X, Wang HJ, Xia XC "An overview on natural polysaccharides with antioxidant properties" -
Current Medicinal Chemistry 20(23) (2013) 2899-2913
Pharmacotherapy using natural substances can be currently regarded as a very promising future alternative to conventional therapy. With the rapid development of biotechnologies and analytical techniques, a great number of methods have been developed for the identification and quantification of the material, extracts, and products of natural ingredients. The advances available today. The need for safer drugs without side effects has led to the use of natural ingredients with proven safety. In recent years, some bioactive polysaccharides isolated from natural sources have attracted much attention in the field of biochemistry and pharmacology. As an example, polysaccharides or their glycoconjugates were shown to exhibit multiple biological activities including anticarcinogenic, anticoagulant, immunostimulating, antioxidant, etc. During the last several years, we have witnessed a steady expansion in the number of publications that focus in antioxidant polysaccharides. This review presents current findings on the latest advancements and trends in antioxidant polysaccharides isolated from the following: plants, fungi, bacteria, animal sources, and algae. Some interesting studies focus on investigation of the relationship between their structure and antioxidant activity, elucidation of their antioxidant mechanism at the molecular level, and improvement of their various biological activities by chemical modifications. Although the mechanism of their antioxidant action is still not completely clear, these polysaccharides are suggested to enhance cell-mediated immune responses in vivo and in vitro and act as biological response modifiers.
polysaccharides, natural, Antioxidant, reactive oxygen species (ROS)
NCBI PubMed ID: 23627941Publication DOI: 10.2174/0929867311320230006Journal NLM ID: 9440157Publisher: Saif Zone, Sharjah, U.A.E.: Bentham Science Publishers
Correspondence: Liu YM
Institutions: Engineering and Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Gansu, China, Key Lab of New Animal Drug Project of Gansu Province, Gansu, China, Key Lab of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutics Sciences of Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China
Methods: GC-MS, NMR, HPAEC, GC, MS, FTIR, extraction, MTT
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