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Timoshina OY, Shneider MM, Evseev PV, Shchurova AS, Shelenkov AA, Mikhailova YV, Sokolova OS, Kasimova AA, Arbatsky NP, Dmitrenok AS, Knirel YA, Miroshnikov KA, Popova AV
Novel Acinetobacter baumannii Bacteriophage Aristophanes Encoding Structural Polysaccharide Deacetylase
Viruses 13(9) (2021)
1688
|
a-D-Glcp-(1-2)-a-L-Rhap-(1-3)-+
|
-2)-b-D-Manp-(1-4)-b-D-Glcp-(1-3)-a-L-6dTalp-(1-3)-b-D-GlcpNAc-(1- |
← revised structure
Show graphically |
Acinetobacter baumannii K26 KZ-1098
(Ancestor NCBI TaxID 470,
species name lookup)
Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: nosocomial infections [ICD11:
XB25 
];
infection due to Acinetobacter baumannii [ICD11:
XN8LS ]
The structure was elucidated in this paperNCBI PubMed ID: 34578271Publication DOI: 10.3390/v13091688Journal NLM ID: 101509722Publisher: Basel, Switzerland: MDPI
Correspondence: popova_nastya86
mail.ru
Institutions: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia, Central Scientific Research Institute of Epidemiology, Novogireevskaya 3a, 111123 Moscow, Russia, Biology Department, Lomonosov Moscow State University, Leninskie Gory 1, 119234 Moscow, Russia, Moscow Institute of Physics and Technology, National Research University, Institutskiy per. 9, Dolgoprudny, 141700 Moscow, Russia, Biology Department, Shenzhen MSU-BIT University, 1 International University Park Road, Longgang District, Shenzhen 518172, China, State Research Center for Applied Microbiology and Biotechnology, 24 'Quarter A' Territory, Obolensk, City District Serpukhov, 142279 Moscow, Russia
Acinetobacter baumannii appears to be one of the most crucial nosocomial pathogens. A possible component of antimicrobial therapy for infections caused by extremely drug-resistant A. baumannii strains may be specific lytic bacteriophages or phage-derived enzymes. In the present study, we observe the biological features, genomic organization, and phage-host interaction strategy of novel virulent bacteriophage Aristophanes isolated on A. baumannii strain having K26 capsular polysaccharide structure. According to phylogenetic analysis phage Aristophanes can be classified as a representative of a new distinct genus of the subfamily Beijerinckvirinae of the family Autographiviridae. This is the first reported A. baumannii phage carrying tailspike deacetylase, which caused O-acetylation of one of the K26 sugar residues.
capsular polysaccharide, Acinetobacter baumannii, bacteriophage, deacetylase, capsular type
Structure type: polymer chemical repeating unit
Location inside paper: Fig. 7(A)
The structure in this paper was incorrect:
Compound class: CPS
Contained glycoepitopes: IEDB_135813,IEDB_136105,IEDB_137340,IEDB_137485,IEDB_141807,IEDB_142488,IEDB_144983,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_152206,IEDB_225177,IEDB_885823,IEDB_983930,IEDB_983931,SB_192,SB_44,SB_72
Methods: 13C NMR, 1H NMR, NMR-2D, PCR, de-O-acetylation, GPC, bioinformatic analysis, phylogenetic analysis, sequencing, TEM, phage characterization, depolymerization by phage, phage genome annotation
Enzymes that release or process the structure: Aristophanes_gp41
Comments, role: O-deacetylation of the CPS by bacteriophage deacetylase Aristophanes_gp41.
Related record ID(s): 10951
NCBI Taxonomy refs (TaxIDs): 470
Show glycosyltransferases
There is only one chemically distinct structure:
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Timoshina OY, Shneider MM, Evseev PV, Shchurova AS, Shelenkov AA, Mikhailova YV, Sokolova OS, Kasimova AA, Arbatsky NP, Dmitrenok AS, Knirel YA, Miroshnikov KA, Popova AV
Novel Acinetobacter baumannii Bacteriophage Aristophanes Encoding Structural Polysaccharide Deacetylase
Viruses 13(9) (2021)
1688
|
a-D-Glcp-(1-2)-a-L-Rhap-(1-3)-+
|
-2)-b-D-Manp-(1-4)-b-D-Glcp-(1-3)-a-L-6dTalp4Ac-(1-3)-b-D-GlcpNAc-(1- |
← revised structure
Show graphically |
Acinetobacter baumannii K26 KZ-1098
(Ancestor NCBI TaxID 470,
species name lookup)
Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: nosocomial infections [ICD11:
XB25 ];
infection due to Acinetobacter baumannii [ICD11:
XN8LS ]
NCBI PubMed ID: 34578271Publication DOI: 10.3390/v13091688Journal NLM ID: 101509722Publisher: Basel, Switzerland: MDPI
Correspondence: popova_nastya86
mail.ru
Institutions: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia, Central Scientific Research Institute of Epidemiology, Novogireevskaya 3a, 111123 Moscow, Russia, Biology Department, Lomonosov Moscow State University, Leninskie Gory 1, 119234 Moscow, Russia, Moscow Institute of Physics and Technology, National Research University, Institutskiy per. 9, Dolgoprudny, 141700 Moscow, Russia, Biology Department, Shenzhen MSU-BIT University, 1 International University Park Road, Longgang District, Shenzhen 518172, China, State Research Center for Applied Microbiology and Biotechnology, 24 'Quarter A' Territory, Obolensk, City District Serpukhov, 142279 Moscow, Russia
Acinetobacter baumannii appears to be one of the most crucial nosocomial pathogens. A possible component of antimicrobial therapy for infections caused by extremely drug-resistant A. baumannii strains may be specific lytic bacteriophages or phage-derived enzymes. In the present study, we observe the biological features, genomic organization, and phage-host interaction strategy of novel virulent bacteriophage Aristophanes isolated on A. baumannii strain having K26 capsular polysaccharide structure. According to phylogenetic analysis phage Aristophanes can be classified as a representative of a new distinct genus of the subfamily Beijerinckvirinae of the family Autographiviridae. This is the first reported A. baumannii phage carrying tailspike deacetylase, which caused O-acetylation of one of the K26 sugar residues.
capsular polysaccharide, Acinetobacter baumannii, bacteriophage, deacetylase, capsular type
Structure type: polymer chemical repeating unit
Location inside paper: Fig. 7(A)
The structure in this paper was incorrect:
Compound class: CPS
Contained glycoepitopes: IEDB_135813,IEDB_136105,IEDB_137340,IEDB_137485,IEDB_141807,IEDB_142488,IEDB_144983,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_152206,IEDB_225177,IEDB_885823,IEDB_983930,IEDB_983931,SB_192,SB_44,SB_72
Methods: 13C NMR, 1H NMR, NMR-2D, PCR, de-O-acetylation, GPC, bioinformatic analysis, phylogenetic analysis, sequencing, TEM, phage characterization, depolymerization by phage, phage genome annotation
Related record ID(s): 9789
NCBI Taxonomy refs (TaxIDs): 470
Show glycosyltransferases
There is only one chemically distinct structure:
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