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1. (Article ID: 9967)
Nishie K, Fitzpatrick TJ, Swain AP, Keyl AC
Positive inotropic action of Solanaceae glycoalkaloids
Research Communications in Chemical Pathology and Pharmacology 15 (1976)
601-607
Six glycoalkaloids and one aglycone were tested for cardiotonic activities and compared with K-strophanthoside by use of the isolated frog heart. The decreasing order of potency was as follows: K-strophanthoside greater than tomatine greater than α-chaconine=α-solanine greater than demissine=commersonine greater than β-chaconine greater than solanidine. Cardiotonic activity was directly related to the number of sugars in the molecule in which the glycoalkaloids had a common aglycone. On the other hand, glycoalkaloids with dissimilar aglycones, but with identical sugars, such as tomatine and demissine, differed significantly with respect to cardiotonic potency. Apparently, therefore, the cardiotonic activity of glycoalkaloids on the frog heart is determined by the nature of the aglycone and the number of sugars and not by the kinds of sugars or their stereochemical configuration.
NCBI PubMed ID: 1087041Journal NLM ID: 0244734Publisher: Pjd Publications
The publication contains the following compound(s):
- Compound ID: 24114
|
b-D-Glcp-(1-3)-+
|
b-D-Glcp-(1-2)-b-D-Glcp-(1-4)-b-D-Galp-(1-3)-Subst
Subst = demissidine = SMILES C[C@@]12[C@@]([H])(C[C@@]3([H])[C@]2([H])[C@H](C)[C@]4([H])N3C[C@@H](C)CC4)[C@@](CC[C@]5([H])[C@@]6(CC{3}[C@H](O)C5)C)([H])[C@]6([H])CC1 |
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Structure type: oligomer
Trivial name: commersonine
Compound class: saponin glycoside
Reference(s) to other database(s): CCSD:
8482, CBank-STR:12168
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