Found 8 structures.
Displayed structures from 1 to 8
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1. Compound ID: 1388
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b-L-Fucp-(1-3)-+
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+
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b-L-Fucp-(1-3)-+ |
| |
a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1-3)-D-Ery-ol |
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Structure type: oligomer
Trivial name: multivalent sialyl Lex epitopes
Contained glycoepitopes: IEDB_114707,IEDB_130646,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391966,IEDB_140108,IEDB_140110,IEDB_140122,IEDB_141588,IEDB_141794,IEDB_141807,IEDB_142351,IEDB_142487,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_146100,IEDB_146664,IEDB_149144,IEDB_149174,IEDB_150933,IEDB_151531,IEDB_152214,IEDB_190606,IEDB_423097,IEDB_423120,IEDB_983931,SB_115,SB_116,SB_131,SB_145,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_187,SB_192,SB_195,SB_30,SB_39,SB_6,SB_68,SB_7,SB_84,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 434
Zou W, Li JJ, Larocque S, Jennings HJ "Construction of multivalent sialyl Lex from the type Ia group B Streptococcus capsular polysaccharide" -
Carbohydrate Research 332(3) (2001) 249-255
The type Ia group B Streptococcus (GBSIa) capsular polysaccharide was specifically degraded by partial Smith oxidation of 2,3-diol of the Glc in the backbone to fragments representing asialo core repeating units. Sialylation of these oligomers furnished GBSIa multiple repeating units. One, two and three repeating units of GBSIa were obtained pure, and the higher oligomers were obtained as mixtures. After enzymatic fucosylation oligosaccharides carrying bivalent, trivalent and other multivalent sialyl Le(x) epitopes presented as appendages on an oligolactoside scaffold were obtained
Streptococcus, oligosaccharide synthesis, degradation, enzymatic glycosylation, group B streptococcal polysaccharide, multivalent sialyl Le(x)
NCBI PubMed ID: 11376605Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: wei.zou@nrc.ca
Institutions: Institute for Biological Sciences, National Research Council of Canada, Ontario, K1A 0R6, Ottawa, Canada
Methods: 1H NMR, GLC-MS, ESI-MS, Smith degradation, sialylation
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2. Compound ID: 1389
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b-L-Fuc-(1-3)-+
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+
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b-L-Fucp-(1-3)-+ |
| |
a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1--/1,2-O-hydroxyethylidene-D-erythritol/ |
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Structure type: oligomer
Aglycon: 1,2-O-hydroxyethylidene-D-erythritol
Trivial name: multivalent sialyl Lex epitopes
Contained glycoepitopes: IEDB_130646,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391966,IEDB_140108,IEDB_140110,IEDB_140122,IEDB_141588,IEDB_141794,IEDB_141807,IEDB_142351,IEDB_142487,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_146100,IEDB_146664,IEDB_149144,IEDB_149174,IEDB_150933,IEDB_151531,IEDB_152214,IEDB_190606,IEDB_423097,IEDB_423120,IEDB_983931,SB_115,SB_116,SB_131,SB_145,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_187,SB_192,SB_195,SB_30,SB_39,SB_6,SB_68,SB_7,SB_84,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 434
Zou W, Li JJ, Larocque S, Jennings HJ "Construction of multivalent sialyl Lex from the type Ia group B Streptococcus capsular polysaccharide" -
Carbohydrate Research 332(3) (2001) 249-255
The type Ia group B Streptococcus (GBSIa) capsular polysaccharide was specifically degraded by partial Smith oxidation of 2,3-diol of the Glc in the backbone to fragments representing asialo core repeating units. Sialylation of these oligomers furnished GBSIa multiple repeating units. One, two and three repeating units of GBSIa were obtained pure, and the higher oligomers were obtained as mixtures. After enzymatic fucosylation oligosaccharides carrying bivalent, trivalent and other multivalent sialyl Le(x) epitopes presented as appendages on an oligolactoside scaffold were obtained
Streptococcus, oligosaccharide synthesis, degradation, enzymatic glycosylation, group B streptococcal polysaccharide, multivalent sialyl Le(x)
NCBI PubMed ID: 11376605Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: wei.zou@nrc.ca
Institutions: Institute for Biological Sciences, National Research Council of Canada, Ontario, K1A 0R6, Ottawa, Canada
Methods: 1H NMR, GLC-MS, ESI-MS, Smith degradation, sialylation
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3. Compound ID: 1390
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b-L-Fucp-(1-3)-+
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+
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b-L-Fucp-(1-3)-+ |
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+ |
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b-L-Fucp-(1-3)-+ | |
| | |
a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1-3)-D-Ery-ol |
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Structure type: oligomer
Trivial name: multivalent sialyl Lex epitopes
Contained glycoepitopes: IEDB_114707,IEDB_130646,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391966,IEDB_140108,IEDB_140110,IEDB_140122,IEDB_141588,IEDB_141794,IEDB_141807,IEDB_142351,IEDB_142487,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_146100,IEDB_146664,IEDB_149144,IEDB_149174,IEDB_150933,IEDB_151531,IEDB_152214,IEDB_190606,IEDB_423097,IEDB_423120,IEDB_983931,SB_115,SB_116,SB_131,SB_145,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_187,SB_192,SB_195,SB_30,SB_39,SB_6,SB_68,SB_7,SB_84,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 434
Zou W, Li JJ, Larocque S, Jennings HJ "Construction of multivalent sialyl Lex from the type Ia group B Streptococcus capsular polysaccharide" -
Carbohydrate Research 332(3) (2001) 249-255
The type Ia group B Streptococcus (GBSIa) capsular polysaccharide was specifically degraded by partial Smith oxidation of 2,3-diol of the Glc in the backbone to fragments representing asialo core repeating units. Sialylation of these oligomers furnished GBSIa multiple repeating units. One, two and three repeating units of GBSIa were obtained pure, and the higher oligomers were obtained as mixtures. After enzymatic fucosylation oligosaccharides carrying bivalent, trivalent and other multivalent sialyl Le(x) epitopes presented as appendages on an oligolactoside scaffold were obtained
Streptococcus, oligosaccharide synthesis, degradation, enzymatic glycosylation, group B streptococcal polysaccharide, multivalent sialyl Le(x)
NCBI PubMed ID: 11376605Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: wei.zou@nrc.ca
Institutions: Institute for Biological Sciences, National Research Council of Canada, Ontario, K1A 0R6, Ottawa, Canada
Methods: 1H NMR, GLC-MS, ESI-MS, Smith degradation, sialylation
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4. Compound ID: 1391
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b-L-Fucp-(1-3)-+
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+
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b-L-Fucp-(1-3)-+ |
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+ |
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b-L-Fucp-(1-3)-+ | |
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1--/1,2-O-hydroxyethylidene-D-erythritol/ |
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Structure type: oligomer
Aglycon: 1,2-O-hydroxyethylidene-D-erythritol
Trivial name: multivalent sialyl Lex epitopes
Contained glycoepitopes: IEDB_130646,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391966,IEDB_140108,IEDB_140110,IEDB_140122,IEDB_141588,IEDB_141794,IEDB_141807,IEDB_142351,IEDB_142487,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_146100,IEDB_146664,IEDB_149144,IEDB_149174,IEDB_150933,IEDB_151531,IEDB_152214,IEDB_190606,IEDB_423097,IEDB_423120,IEDB_983931,SB_115,SB_116,SB_131,SB_145,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_187,SB_192,SB_195,SB_30,SB_39,SB_6,SB_68,SB_7,SB_84,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 434
Zou W, Li JJ, Larocque S, Jennings HJ "Construction of multivalent sialyl Lex from the type Ia group B Streptococcus capsular polysaccharide" -
Carbohydrate Research 332(3) (2001) 249-255
The type Ia group B Streptococcus (GBSIa) capsular polysaccharide was specifically degraded by partial Smith oxidation of 2,3-diol of the Glc in the backbone to fragments representing asialo core repeating units. Sialylation of these oligomers furnished GBSIa multiple repeating units. One, two and three repeating units of GBSIa were obtained pure, and the higher oligomers were obtained as mixtures. After enzymatic fucosylation oligosaccharides carrying bivalent, trivalent and other multivalent sialyl Le(x) epitopes presented as appendages on an oligolactoside scaffold were obtained
Streptococcus, oligosaccharide synthesis, degradation, enzymatic glycosylation, group B streptococcal polysaccharide, multivalent sialyl Le(x)
NCBI PubMed ID: 11376605Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: wei.zou@nrc.ca
Institutions: Institute for Biological Sciences, National Research Council of Canada, Ontario, K1A 0R6, Ottawa, Canada
Methods: 1H NMR, GLC-MS, ESI-MS, Smith degradation, sialylation
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5. Compound ID: 1392
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b-L-Fucp-(1-3)-+
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+
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b-L-Fucp-(1-3)-+ |
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+ |
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b-L-Fucp-(1-3)-+ | |
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+ | |
| | |
b-L-Fucp-(1-3)-+ | | |
| | | |
a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1-3)-D-Ery-ol |
Show graphically |
Structure type: oligomer
Trivial name: multivalent sialyl Lex epitopes
Contained glycoepitopes: IEDB_114707,IEDB_130646,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391966,IEDB_140108,IEDB_140110,IEDB_140122,IEDB_141588,IEDB_141794,IEDB_141807,IEDB_142351,IEDB_142487,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_146100,IEDB_146664,IEDB_149144,IEDB_149174,IEDB_150933,IEDB_151531,IEDB_152214,IEDB_190606,IEDB_423097,IEDB_423120,IEDB_983931,SB_115,SB_116,SB_131,SB_145,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_187,SB_192,SB_195,SB_30,SB_39,SB_6,SB_68,SB_7,SB_84,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 434
Zou W, Li JJ, Larocque S, Jennings HJ "Construction of multivalent sialyl Lex from the type Ia group B Streptococcus capsular polysaccharide" -
Carbohydrate Research 332(3) (2001) 249-255
The type Ia group B Streptococcus (GBSIa) capsular polysaccharide was specifically degraded by partial Smith oxidation of 2,3-diol of the Glc in the backbone to fragments representing asialo core repeating units. Sialylation of these oligomers furnished GBSIa multiple repeating units. One, two and three repeating units of GBSIa were obtained pure, and the higher oligomers were obtained as mixtures. After enzymatic fucosylation oligosaccharides carrying bivalent, trivalent and other multivalent sialyl Le(x) epitopes presented as appendages on an oligolactoside scaffold were obtained
Streptococcus, oligosaccharide synthesis, degradation, enzymatic glycosylation, group B streptococcal polysaccharide, multivalent sialyl Le(x)
NCBI PubMed ID: 11376605Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: wei.zou@nrc.ca
Institutions: Institute for Biological Sciences, National Research Council of Canada, Ontario, K1A 0R6, Ottawa, Canada
Methods: 1H NMR, GLC-MS, ESI-MS, Smith degradation, sialylation
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6. Compound ID: 1393
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b-L-Fucp-(1-3)-+
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+
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b-L-Fucp-(1-3)-+ |
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+ |
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b-L-Fucp-(1-3)-+ | |
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-+ | |
| | |
b-L-Fucp-(1-3)-+ | | |
| | | |
a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1-4)-b-D-Glcp-(1-4)-b-D-Galp-(1--/1,2-O-hydroxyethylidene-D-erythritol/ |
Show graphically |
Structure type: oligomer
Aglycon: 1,2-O-hydroxyethylidene-D-erythritol
Trivial name: multivalent sialyl Lex epitopes
Contained glycoepitopes: IEDB_130646,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391966,IEDB_140108,IEDB_140110,IEDB_140122,IEDB_141588,IEDB_141794,IEDB_141807,IEDB_142351,IEDB_142487,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_146100,IEDB_146664,IEDB_149144,IEDB_149174,IEDB_150933,IEDB_151531,IEDB_152214,IEDB_190606,IEDB_423097,IEDB_423120,IEDB_983931,SB_115,SB_116,SB_131,SB_145,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_187,SB_192,SB_195,SB_30,SB_39,SB_6,SB_68,SB_7,SB_84,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 434
Zou W, Li JJ, Larocque S, Jennings HJ "Construction of multivalent sialyl Lex from the type Ia group B Streptococcus capsular polysaccharide" -
Carbohydrate Research 332(3) (2001) 249-255
The type Ia group B Streptococcus (GBSIa) capsular polysaccharide was specifically degraded by partial Smith oxidation of 2,3-diol of the Glc in the backbone to fragments representing asialo core repeating units. Sialylation of these oligomers furnished GBSIa multiple repeating units. One, two and three repeating units of GBSIa were obtained pure, and the higher oligomers were obtained as mixtures. After enzymatic fucosylation oligosaccharides carrying bivalent, trivalent and other multivalent sialyl Le(x) epitopes presented as appendages on an oligolactoside scaffold were obtained
Streptococcus, oligosaccharide synthesis, degradation, enzymatic glycosylation, group B streptococcal polysaccharide, multivalent sialyl Le(x)
NCBI PubMed ID: 11376605Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: wei.zou@nrc.ca
Institutions: Institute for Biological Sciences, National Research Council of Canada, Ontario, K1A 0R6, Ottawa, Canada
Methods: 1H NMR, GLC-MS, ESI-MS, Smith degradation, sialylation
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7. Compound ID: 3758
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Par-(1-3)-+
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-2)-D-Manp-(1-4)-D-Manp-(1-3)-L-Fucp-(1-3)-D-GlcpNAc-(1- |
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Structure type: polymer chemical repeating unit
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_130701,IEDB_135813,IEDB_136035,IEDB_136045,IEDB_137340,IEDB_137485,IEDB_141807,IEDB_142489,IEDB_144562,IEDB_144983,IEDB_145669,IEDB_150092,IEDB_151531,IEDB_152206,IEDB_152214,IEDB_174333,IEDB_423097,IEDB_983930,SB_44,SB_67,SB_72,SB_86
The structure is contained in the following publication(s):
- Article ID: 1432
Skurnik M, Peippo A, Ervelä E "Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y-pseudotuberculosis serotype O:1b" -
Molecular Microbiology 37(2) (2000) 316-330
One of the most virulent and feared bacterial pathogens is Yersinia pestis, the aetiologic agent of bubonic plague. Characterization of the O-antigen gene clusters of 21 serotypes of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Y. pestis showed that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b. The nucleotide sequences of both gene clusters (about 20.5 kb each) were determined and compared to identify the differences that caused the silencing of the Y. pestis gene cluster. At the nucleotide sequence level, the loci were 98.9+ACU- identical and, of the 17 biosynthetic genes identified from the O:1b gene cluster, five were inactivated in the Y. pestis cluster, four by insertions or deletions of one nucleotide and one by a deletion of 62 nucleotides. Apparently, the expression of the O-antigen is not beneficial for the virulence or to the lifestyle of Y. pestis and, therefore, as one step in the evolution of Y. pestis, the O-antigen gene cluster was inactivated.
gene, characterization, serotype, O-antigen, O antigen, cluster, gene cluster, Yersinia pseudotuberculosis, Bacillus, Yersinia, Yersinia pestis, Plague
NCBI PubMed ID: 10931327Journal NLM ID: 8712028Publisher: Blackwell Publishing
Correspondence: mskurnik@utu.fi
Institutions: Department of Medical Biochemistry, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland.
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8. Compound ID: 16242
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a-D-Quip-(1-3)-a-D-GlcpA-(1-2)-+
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b-D-Glcp-(1-2)-+ |
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-3)-a-L-Rhap-(1-3)-b-L-Fucp-(1-3)-b-D-GlcpNAc-(1- |
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Structure type: polymer chemical repeating unit
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_115136,IEDB_135813,IEDB_136105,IEDB_137340,IEDB_140630,IEDB_141807,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_146664,IEDB_151531,IEDB_152214,IEDB_225177,IEDB_423097,IEDB_885823,IEDB_983931,SB_192,SB_86
The structure is contained in the following publication(s):
- Article ID: 6298
Qin C, Hu B, Xu Y, Zhao C, Hao W, Wang J, Guo X, Li R, Hu J, Yin J "Structural Elucidation and genetic identification of the O-antigen from a novel serogroup of Escherichia coli strain 2017LL031" -
Carbohydrate Research 517 (2022) 108577
The O-antigen is an important virulence factor involved in the survival, virulence and invasion of bacteria. The bacterial serological types are highly dependent on these surface-exposed and structurally unique O-antigen structures. In this work, the structure of O-antigen from an Escherichia coli strain 2017LL031 was elucidated as a hexasaccharide repeating unit: →3)-[β-D-Glcp-(1→2)]-α-L-Rhap-(1→3)-[α-D-Quip-(1→3)-α-D-GlcpA-(1→2)]-β-L-Fucp-(1→3)-β-D-GlcpNAc-(1→, which is completely different from all known E. coli serogroups. The O-antigen gene cluster (O-AGC) of 2017LL031 was also analyzed and correlates well to its O-Ag. Moreover, the O-AGC of 2017LL031 was deleted and its role in O-Ag biosynthesis was confirmed experimentally. Taken together, our results present that a novel E.coli serotype 2017LL031 is identified.
structure, serotype, O-antigen, Escherichia coli, O-antigen gene cluster
NCBI PubMed ID: 35569241Publication DOI: 10.1016/j.carres.2022.108577Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: Renpeng Li
; Jing Hu
Institutions: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Lihu Ave. 1800, Wuxi, 214122, China, Shandong Center for Disease Control and Prevention, 16992 City Ten Road, Jinan, 250014, Shandong, PR China, Center for Disease Control and Prevention of LanLing City, 1 City Huibao Road, Lanling, 276000, Lanling, Shandong, PR China, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23, Hongda Street, TEDA, Tianjin, China, Wuxi School of Medicine, Jiangnan University, Lihu Ave. 1800, Wuxi, 214122, China
Methods: 13C NMR, 1H NMR, NMR-2D, PCR, SDS-PAGE, sugar analysis, HPSEC, HPAEC-PAD, genome sequencing, annotation
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Total list of structure IDs on all result pages of the current query:
Total list of corresponding CSDB IDs (record IDs):
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