Found 5 structures.
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1. Compound ID: 16450
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a-D-Glcp-(1-6)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-D-Man |
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Structure type: oligomer
Trivial name: glucomannan
Compound class: glucomannan
Contained glycoepitopes: IEDB_130701,IEDB_136104,IEDB_137485,IEDB_140116,IEDB_141795,IEDB_141830,IEDB_141835,IEDB_141836,IEDB_142488,IEDB_143632,IEDB_144983,IEDB_144998,IEDB_146664,IEDB_152206,IEDB_164480,IEDB_76933,IEDB_983930,IEDB_983931,SB_136,SB_192,SB_196,SB_44,SB_67,SB_72
The structure is contained in the following publication(s):
- Article ID: 6395
Ogawa K, Matsuda K, Tamari K, Kiyo-oka S "Studies on the glucomannan from Candida utilis. Part III. Immunochemical analysis of the glucomannan from Candida utilis" -
Agricultural and Biological Chemistry 54 (1990) 593-597
A glucomannan isolated from a Candida utilis mutant having a new chemotype was further studied by inhibition of the homologous precipitin reaction with oligosaccharides obtained from the glucomannan by partial acid hydrolysis and controlled acetolysis. Oligosaccharides having at least two consecutive α-(1----2)-linked mannose residues at the non-reducing end and gluco-manno-pentasaccharide were effective inhibitors. Thus, it appears that the glucomannan had two groups of antigenic determinants, one corresponding to the side chains of two, three, and four mannose units connected by α-(1----2)-linkage, and the other corresponding to a side chain composed of an O-α-D-glucopyranosyl-(1----6)-O-α-D-mannopyranosyl- (1----2)-O-α-D-mannopyranosyl-(1----2)-D-mannose unit. These results support a probable structure of repeating units for the glucomannan presented previously. The relative susceptibility of intersaccharidic linkages to acid hydrolysis in the mannan is discussed.
NCBI PubMed ID: 1368530Journal NLM ID: 0370452Publisher: Tokyo: Agricultural Chemical Society Of Japan
Institutions: Department of Fundamental Science, College of Science and Engineering, Iwaki Meisei University, Fukushima, Japan
Methods: acid hydrolysis, precipitin reaction
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2. Compound ID: 17882
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?%D-Glcp-(1-6)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-+
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?%a-D-Manp-(1-2)-?%a-D-Manp-(1-2)-?%a-D-Manp-(1-2)-a-D-Manp-(1-2)-+ |
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-6)-a-D-Manp-(1-6)-a-D-Manp-(1-6)-a-D-Manp-(1-6)-a-D-Manp-(1-6)-a-D-Manp-(1-6)-a-D-Manp-(1- |
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Structure type: structural motif or average structure
; 30000-70000
Trivial name: glucomannan
Compound class: cell wall polysaccharide
Contained glycoepitopes: IEDB_130701,IEDB_136104,IEDB_140116,IEDB_141793,IEDB_141795,IEDB_141828,IEDB_141829,IEDB_141830,IEDB_141831,IEDB_141832,IEDB_141833,IEDB_141834,IEDB_141835,IEDB_141836,IEDB_142488,IEDB_143632,IEDB_144983,IEDB_144998,IEDB_146664,IEDB_152206,IEDB_153220,IEDB_153762,IEDB_153763,IEDB_164480,IEDB_76933,IEDB_857735,IEDB_983930,IEDB_983931,SB_136,SB_191,SB_192,SB_196,SB_198,SB_44,SB_67,SB_72
The structure is contained in the following publication(s):
- Article ID: 6985
Ruszova E, Pavek S, Hajkova V, Jandova S, Velebny V, Papezikova I, Kubala L "Photoprotective effects of glucomannan isolated from Candida utilis" -
Carbohydrate Research 343(3) (2008) 501-511
Glucomannans belong to yeast and fungal cell wall polysaccharides with known immunostimulatory and radioprotective effects. However, glucomannan protective effects against pathological consequences of skin exposure to short wavelength solar light, ultraviolet (UV) radiation, are unclear. Herein, a highly branched glucomannan (GM) isolated from the cell wall of Candida utilis, a member of the alpha-(1-->6)-D-mannan group, was tested for its photoprotective effects in an in vitro model of UVB-irradiated human keratinocytes and an in vivo model of UV-induced erythema formation in human volunteers. GM suppressed the UVB-induced decrease of keratinocyte viability, which was connected with the suppression of UVB-induced keratinocyte apoptosis. GM reduced UVB-mediated caspase activation together with suppression of DNA fragment release into the cytoplasm. Furthermore, GM suppressed UVB-induced gene expression of pro-inflammatory markers including nuclear factor kappa B, inducible nitric oxide synthase, interleukins 8 and 1, together with suppression of prostaglandin E2 and interleukin 1alpha protein release. In vivo, GM decreased UV-induced skin erythema formation, which was correlated with a decrease of phosholipase A(2) activity within the stratum corneum. It could be concluded that GM isolated from C. utilis possesses significant photoprotective effects on human keratinocytes in vitro as well as in vivo.
polysaccharide, apoptosis, Glucomannan, Candida utilis, HaCaT keratinocytes, UV-protection
NCBI PubMed ID: 18067882Publication DOI: 10.1016/j.carres.2007.11.010Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: ruszova@contipro.cz (Ema Ruszova)
Institutions: CPN spol. s.r.o, 561 02 Dolni Dobrouc 401, Czech Republic, Institute of Biophysics Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
Methods: DNA techniques, ELISA, genetic methods, extraction, enzymatic analysis, statistical analysis, microarray analysis, measurement of cytokines, UVB irradiation
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3. Compound ID: 21819
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a-D-Manp-(1-6)-a-D-Manp-(1-6)-+
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a-D-Glcp-(1-4)-a-D-Glcp-(1-6)-+ |
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a-D-Glcp-(1-6)-a-D-Glcp-(1-6)-+ | |
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b-D-Galf-(1-6)-+ | | |
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b-D-Galf-(1-2)-b-D-Galf-(1-2)-b-D-Galf-(1-6)-b-D-Galf-(1-6)-+ | | |
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-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1- |
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Structure type: structural motif or average structure
; 18300
Compound class: polysaccharide, glucogalactomannan
Contained glycoepitopes: IEDB_130701,IEDB_136095,IEDB_136104,IEDB_137472,IEDB_140116,IEDB_140629,IEDB_141793,IEDB_141795,IEDB_141828,IEDB_141830,IEDB_141834,IEDB_141835,IEDB_141836,IEDB_142488,IEDB_143632,IEDB_144983,IEDB_144998,IEDB_146664,IEDB_149176,IEDB_152206,IEDB_153220,IEDB_164480,IEDB_190606,IEDB_76933,IEDB_983930,IEDB_983931,SB_136,SB_192,SB_196,SB_198,SB_44,SB_67,SB_72
The structure is contained in the following publication(s):
- Article ID: 8907
Zhou D, Li P, Dong Z, Wang T, Sun K, Zhao Y, Wang B, Chen Y "Structure and immunoregulatory activity of β-D-galactofuranose-containing polysaccharides from the medicinal fungus Shiraia bambusicola" -
International Journal of Biological Macromolecules 129 (2019) 530-537
To explore bioactive polysaccharides from medicinal fungi, a homogeneous heteropolysaccharide SB1-1 was extracted from the stroma of Shiraia bambusicola by enzyme assisted extraction, ethanol precipitation, anion-exchange and size-exclusion chromatographies. Chemical and spectroscopic analyses showed that SB1-1 was a neutral polysaccharide composed of mannose, glucose and galactose at a molar ratio of 1.1:1.9:1.0, and had a molecular weight of 18.3 kDa. SB1-1 was composed of a mannan core and glucose and galactose side chains. The mannan core was composed of (1→2)-α-Manp substituted by the side chains (1→6)-α-D-Manp, (1→4)-α-D-Glcp and (1→6)-α-D-Glcp with different degrees of polymerization at the C-6. The galactose side chains had the backbone of (1→6)-β-D-Galf. There were two branch sites on every five sugars on average at the O-2 of →6)-β-Galf(1→, and the branches consisted of →2)-β-D-Galf(1→ and terminal β-D-Galf(1→. The potential immunomodulatory activities of SB1-1 on RAW264.7 macrophages were investigated. The results showed that SB1-1 could activate macrophage and significantly improve its phagocytic ability by neutral red uptake assay. Additionally, SB1-1 enhanced the productions of IL-1, IL-6, IL-12 and TNF-α in the RAW264.7 macrophages by stimulation of SB1-1, while significantly increased the production of inducible nitric oxide synthase (iNOS) production. This study demonstrated that the galactofuranose-containing polysaccharide SB1-1 from S. bambusicola which is a novel mannogalactoglucan, could enhance the activation of macrophages.
structure, polysaccharide, galactofuranose, macrophages, medical fungi
NCBI PubMed ID: 30710588Publication DOI: 10.1016/j.ijbiomac.2019.01.179Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Correspondence: Chen Y
Institutions: College of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, China, Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhoushan, China, Zhejiang Mariculture Research Institute, Zhoushan, China, Marine School, Ningbo University, Ningbo, China
Methods: 1H NMR, NMR-2D, methylation, IR, acid hydrolysis, extraction, acetylation, methylation analysis, reduction, column chromatography, RP-HPLC, dialysis, determination of NO production, cytokine production, HPGPC, precipitation, macrophage activity assay, phenol-sulfuric acid assay, Bradford method
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4. Compound ID: 22332
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/Variants 2/-+
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-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-
/Variants 0/ is:
Manp-(1-3)-
OR (exclusively)
Arap-(1-3)-
/Variants 1/ is:
Manp-(1-3)-
OR (exclusively)
Arap-(1-3)-
/Variants 2/ is:
{{{-b-D-Galf-(1-2)-}}}b-D-Galf-(1-6)-
OR (exclusively)
a-D-Glcp-(1-4)-{{{-a-D-Glcp6(%)Me-(1-4)-}}}a-D-Glcp-(1-6)-
OR (exclusively)
/Variants 1/-+ /Variants 0/-+
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Arap-(1-4)-{{{-Arap-(1-4)-Arap-(1-4)-}}}Arap-(1-4)-Arap-(1-6)- |
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Structure type: structural motif or average structure
; 18000
Compound class: polysaccharide, galactomannan
Contained glycoepitopes: IEDB_130701,IEDB_136095,IEDB_136104,IEDB_137472,IEDB_137485,IEDB_1394182,IEDB_140116,IEDB_140629,IEDB_141795,IEDB_141830,IEDB_141834,IEDB_141835,IEDB_141836,IEDB_142488,IEDB_143632,IEDB_144983,IEDB_144998,IEDB_146664,IEDB_152206,IEDB_164480,IEDB_190606,IEDB_420417,IEDB_420418,IEDB_420421,IEDB_581506,IEDB_76933,IEDB_857742,IEDB_983930,IEDB_983931,SB_136,SB_192,SB_196,SB_44,SB_67,SB_72
The structure is contained in the following publication(s):
- Article ID: 9236
Chen Y, Wang T, Zhang X, Zhang F, Linhardt RJ "Structural and immunological studies on the polysaccharide from spores of a medicinal entomogenous fungus Paecilomyces cicadae" -
Carbohydrate Polymers 254 (2021) ID 117462
A neutral branched heteropolysaccharide (Pc0-1) was purified from the spores of Paecilomyces cicadae, which parasitized in the bamboo cicada (Platylomia pieli Kato). The structure of Pc0-1 was analyzed by HPLC, IR, methylation and NMR spectroscopy. The results reveal that Pc0-1, with an average molecular weight of 18000 kDa, consists of glucose, galactose, mannose and arabinose in the molar ratio of 8:5:4:1. Some of the glucose residues have methyl modification at O-6 position. The Pc0-1 polysaccharide has a core structure containing 1,2-linked α-D-Manp residues as the backbone and branches at the O-3 and O-6 of the α-D-Manp residues. The inner part of the side-chains is comprised of 1,4-linked α-D-Glcp and 1,4-linked 6-O-Me-α-D-Glcp residues. 1,2-linked β-Galf and minor 1,4-linked Arap and 1,3 or 4-linked Arap residues were occasionally linked at the outside of the side-chains. The side-chains have a single terminal residue of α-D-Glcp, α-Manp, β-Galf or minor Arap (minor). Studies on the bioactivity of Pc0-1 on the macrophages show it exhibit moderate immunostimulating activity through increasing the production of nitric oxide (NO) and enhancing the secretion of major inflammatory cytokines by macrophages, such as TNF-?, IL-1?, IL-6, in RAW 264.7 cells. We examined the effect of Pc0-1 on induced NO and cytokine production in macrophages using anti-PRR antibodies to investigate the membrane receptor for the polysaccharide. The results show that Pc0-1 mainly activates macrophages through their mannose receptor (MR). TLR4 and TLR2 also participated in the recognition of Pc0-1.
structure, macrophages, immunostimulating activity, cell membrane receptor, fungus polysaccharide
NCBI PubMed ID: 33357921Publication DOI: 10.1016/j.carbpol.2020.117462Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: Chen Y
; Linhardt RJ
Institutions: College of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, China, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China, Departments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering, and Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, USA
Methods: 13C NMR, 1H NMR, NMR-2D, methylation, IR, GC-MS, acid hydrolysis, anion-exchange chromatography, HPLC, enzymatic digestion, extraction, acetylation, reduction, dialysis, determination of NO production, cytokine production, cell viability assay, HPGPC, precipitation, derivatization, centrifugation, MTT, ROS measurement
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5. Compound ID: 22391
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b-D-Galf-(1-5)-{{{-b-D-Galf-(1-5)-}}}b-D-Galf-(1-6)-+ /Variants 0/-+
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-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-
/Variants 0/ is:
SUG-(1-3)-b-D-Glcp-(1-6)-
OR (exclusively)
b-D-Galf-(1-6)-
OR (exclusively)
a-D-Manp-(1-6)-
OR (exclusively)
SUG-(1-4)-a-D-Glcp-(1-4)-a-D-Glcp-(1-6)- |
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Structure type: structural motif or average structure
Trivial name: mycelium endopolysaccharide (MPS)
Contained glycoepitopes: IEDB_130701,IEDB_136095,IEDB_136104,IEDB_137472,IEDB_140116,IEDB_140629,IEDB_141793,IEDB_141795,IEDB_141830,IEDB_141834,IEDB_141835,IEDB_141836,IEDB_142488,IEDB_143632,IEDB_144983,IEDB_144998,IEDB_146664,IEDB_147453,IEDB_149137,IEDB_152206,IEDB_153220,IEDB_164480,IEDB_190606,IEDB_76933,IEDB_885812,IEDB_983930,IEDB_983931,SB_136,SB_192,SB_196,SB_198,SB_44,SB_67,SB_72
The structure is contained in the following publication(s):
- Article ID: 9295
Wang N, Wu Y, Jia G, Wang C, Xiao D, Goff HD, Guo Q "Structural characterization and immunomodulatory activity of mycelium polysaccharide from liquid fermentation of Monascus purpureus (Hong Qu)" -
Carbohydrate Polymers 262 (2021) 117945
Alkaline extracted endopolysaccharides (MPS) from Monascus purpureus (Hong Qu) mycelium were successfully separated into four sub-fractions, namely MPS-1 (18.0 %), MPS-2 (27.1 %), MPS-3 (12.6 %) and MPS-4 (14.7 %), by DEAE-Cellulose column chromatography. By combining monosaccharide composition analysis, methylation analysis and 1D & 2D NMR, the structure of sub-fractions was systematically characterized. Both MPS-1 and MPS-2 were comprised of mannose, glucose and galactose in the molar ratio of 1.5:1.6:1.0 and 10.6:1.0:13.8, respectively. The backbone of them both consisted of 2-α-Manp with several different branched chains. However, MPS-1 contained glucose based sugar residues such as 3-Glcp and 4-Glcp which were not shown on MPS-2. The proposed structures of MPS-3 and MPS-4 were not obtained due to the fairly complex molecular structure and relatively low yield. Moreover, based on the RAW 264.7 cells model, MPS-2 could significantly promote cytokines secretion including IL-6, TNF-α, and IL-10 and improve expression levels of the related mRNA.
immunomodulatory activity, Structural characterization, liquid fermentation, Monascus purpureus, mycelium polysaccharide
NCBI PubMed ID: 33838822Publication DOI: 10.1016/j.carbpol.2021.117945Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: Q. Guo
Institutions: State Key Laboratory of Food Nutrition and Safety, School of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, China, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China, Shanghai Engineering Research Center of Food Safety, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China, Department of Food Science, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
Methods: 13C NMR, 1H NMR, NMR-2D, methylation, GC-MS, sugar analysis, FTIR, HPLC, statistical analysis, cytokine assay, qRT-PCR, cell proliferation assay, alkaline extraction, NO assay
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Total list of corresponding CSDB IDs (record IDs):
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