The objectives of this research were analysis of the secondary metabolite produced by Candida albicans and evaluation antibacterial activity. Bioactives are chemical compounds often referred to as secondary metabolites. Thirty nine bioactive compounds were identified in the methanolic extract of Candida albicans. The identification of bioactive chemical compounds is based on the peak area, retention time molecular weight and molecular formula. GC-MS analysis of Candida albicans revealed the existence of the 1,4-Benzendiol, 2,6-bis (1,1-dimethylethyl)-, Thieno[2,3-c]furan-3-carboniterile, 2-amino-4,6-dihydro-4,4,6,6-te, Z-8-Methyl-9-tetradecenoic acid, i-Propyl 9-tetradecenoate, 9,12,15,-Octadecatrienoic, 2-[(trimethylsilyl)oxy]-1-[(trimethyl, 17-Octadecynoic acid, Oxime-, methoxy-phenyl-, Edulanll, p-Menth-1-en-3-one, semicarbazone, 5,7-dodecadiyn-1,12-diol, Methyl 2-O-benzyl-d-arabinofuranoside, Erythritol, d-Glycero-l-gluco-heptose, D-Glucose, 6-O-α-D-galactopyranosyl-, l-Gala-l-ido-octonic lactone, Desulphosingrin, 2(3H)-Furanone, 3-butyldihydro-, β-Hydroxyquebrachamine, 1,4-benzendiol, 2,6-bis(1,1-dimethylethyl)-, 9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol,(3β,5Z,7E)-,N-(4,6-Dimethyl-2-pyrimi-dinyl)-4-(4-nitrobenzylideneamino)benzel, 2,7-Diphenyl-1,6-dioxopyridazino [4,5:2’,3’] pyrrolo[4’,5’-d]pyridazin, 2-Methyl-9-β-D-ribofuranosylhypoxanthine, Ergosta-5, 22-dien-3-ol,acetate,(3β,22E)-, 10-Heptadecen-8-ynoic acid, methyl ester, (E)-, Chromone, 5-hydroxy-6,7,8-trimethoxy-2,3-dimethyl-, 1-Methyl-8-propyl-3,6-diazahomoadamantan-9-ol, 1-(4-Amino-furazan-3-yl)-5-dimethylaminomethyl-1H-[1,2,3]triazole, 5-Bromo-8-[(4-hydroxybenzylidene) amino]quinolone, Carbamic acid, N-methyl-,(6-chloro-2-methyl-1,1-dioxidobenzo), d-Mannose, α-D-Glucopyranoside, O-α-D-glucopyranosyl-(1.fwdarw.3)-β-D-, 12-Methyl-oxa-cyclododecan-2-one, Acetamide, N-methyl-N-[4-[2acetoxymethyl-1-pyrrolidyl]-2-butyn, Acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2butynyl]-, Estra-1,3,5(10)-triene-17β-ol, Curan-17-oic acid, 19,20-dihydroxy-,methyl ester,(19S)-, 2,5,5,8A-Tetramethyl-6,7,8,8atetrahydro-5H-chromen-8-ol and 6-Octadecenoic acid. Proteus mirabilis was very highly antifungal activity (6.19±0.20) mm while Neriumolender (Alkaloids) has maximum zone formation (7.67±0.21) mm against Aspergillus fumigatus.
Candida albicans, antibacterial activity, GC-MS, antifungal activity, secondary metabolites, FT-IR
WWW link: https://www.researchgate.net/publication/306314562_Analysis_of_bioactive_metabolites_from_Candida_albicans_using_GC-MS_and_evaluation_of_antibacterial_activityInstitutions: Department of Genetic Engineering, Al-Qasim Green University, Iraq, College of Science, Al-Qadisyia University, Iraq
Methods: GC-MS, antibacterial assay, antifungal activity test, FT-IR
Found