Found 8 structures.
Displayed structures from 1 to 8
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1. Compound ID: 3063
L-gro-a-D-manHepp-(1-7)-+
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a-D-Galp-(1-6)-+ |
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D-GlcpNAc-(1-6)-D-Galp-(1-4)-D-GlcpNAc-(1-3)-D-Galp-(1-3)-D-GlcpNAc-(1-7)-L-gro-a-D-manHepp-(1-6)-a-D-Glcp-(1-2)-a-D-Glcp-(1-3)-a-D-Glcp-(1-3)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-Kdo |
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Structure type: oligomer
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130646,IEDB_130650,IEDB_130670,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136906,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391962,IEDB_140088,IEDB_140108,IEDB_140122,IEDB_140529,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_142488,IEDB_143794,IEDB_144998,IEDB_145003,IEDB_146664,IEDB_150899,IEDB_151528,IEDB_151531,IEDB_167070,IEDB_190606,IEDB_2189047,IEDB_226811,IEDB_232584,IEDB_885811,IEDB_983931,SB_137,SB_165,SB_166,SB_173,SB_187,SB_192,SB_195,SB_29,SB_30,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 1108
Phillips NJ, Miller TJ, Engstrom JJ, Melaugh W, McLaughlin R, Apicella MA, Gibson BW "Characterization of chimeric lipopolysaccharides from Escherichia coli strain JM109 transformed with lipooligosaccharide synthesis genes (lsg) from Haemophilus influenzae" -
Journal of Biological Chemistry 275(7) (2000) 4747-4758
Previously, we reported the expression of chimeric lipopolysaccharides (LPS) in Escherichia coli strain JM109 (a K-12 strain) transformed with plasmids containing Haemophilus influenzae lipooligosaccharide synthesis genes (lsg) (Abu Kwaik, Y., McLaughlin, R. E., Apicella, M. A., and Spinola, S. M. (1991) Mol. Microbiol. 5, 2475-2480). In this current study, we have analyzed the O-deacylated LPS and free oligosaccharides from three transformants (designated pGEMLOS-4, pGEMLOS-5, and pGEMLOS-7) by matrix-assisted laser desorption ionization, electrospray ionization, and tandem mass spectrometry techniques, along with composition and linkage analyses. These data show that the chimeric LPS consist of the complete E. coli LPS core structure glycosylated on the 7-position of the non-reducing terminal branch heptose with oligosaccharides from H. influenzae. In pGEMLOS-7, the disaccharide Gal 1→3 GlcNAc1→ is added, and in pGEMLOS-5, the structure is extended to Gal 1→4 GlcNAc 1→3 Gal 1→3 GlcNAc1→. PGEMLOS-5 LPS reacts positively with monoclonal antibody 3F11, an antibody that recognizes the terminal disaccharide of lacto-N-neotetraose. In pGEMLOS-4 LPS, the 3F11 epitope is apparently blocked by glycosylation on the 6-position of the terminal Gal with either Gal or GlcNAc. The biosynthesis of these chimeric LPS was found to be dependent on a functional wecA (formerly rfe) gene in E. coli. By using this carbohydrate expression system, we have been able to examine the functions of the lsg genes independent of the effects of other endogenous Haemophilus genes and expressed proteins.
Lipopolysaccharide, synthesis, Haemophilus, Haemophilus influenzae, lipopolysaccharides, Lipooligosaccharide, gene, strain, characterization, Escherichia, Escherichia coli
NCBI PubMed ID: 10671507Publication DOI: 10.1074/jbc.275.7.4747Journal NLM ID: 2985121RPublisher: Baltimore, MD: American Society for Biochemistry and Molecular Biology
Correspondence: gibson@socrates.cgl.ucsf.edu
Institutions: Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA, Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, Department of Microbiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104
Methods: ESI-MS, MALDI-MS, MS/MS, composition analysis, linkage analysis
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2. Compound ID: 6582
Rib-ol-(1--P--3)--+ EtN-(1--P--6)--+
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-?)-/Variants 0/-GlcpNAc-(1-3)-Glcp-(1-3)-GlcpNAc-(1-
/Variants 0/ is:
Galp-(1-4)-
OR (exclusively)
Galp-(1-3)- |
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Structure type: structural motif or average structure
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_114703,IEDB_120354,IEDB_123890,IEDB_130646,IEDB_135813,IEDB_136044,IEDB_136906,IEDB_137340,IEDB_137472,IEDB_1391962,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_142488,IEDB_143794,IEDB_144998,IEDB_144999,IEDB_145003,IEDB_146664,IEDB_150899,IEDB_151528,IEDB_151531,IEDB_167070,IEDB_190606,IEDB_241103,IEDB_241107,IEDB_241118,IEDB_885811,IEDB_983931,SB_137,SB_165,SB_166,SB_173,SB_187,SB_192,SB_195,SB_29,SB_30,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 2969
Gmeiner J "The ribitol-phosphate-containing lipopolysaccharide from Proteus mirabilis, strain D52. Investigations of O-specific chains" -
European Journal of Biochemistry 74 (1977) 171-180
A soluble hydrophilic lipopolysaccharide, termed lipopolysaccharide II, isolated from Proteus mirabilis, strain D52 contained N-acetylglucosamine, glucose, galactose, ribitol phosphate and ethanolamine phosphate as constituents of the O-specific polysaccharide. Periodate oxidation studies were carried out on the polymer before and after dephosphorylation with hydrofluoric acid and on oligosaccharides derived from the polymer by partial acid hydrolysis. The results obtained indicate that the polysaccharide chain consists of the chemical repeating unit Gal-1,3(4)-GlcNAc-1,3-Glc-1,3-GlcNAc-, where GlcNAc stands for N-acetylglucosamine. Whereas the galactose residue is substituted at C-3 by ribitol phosphate, the glucose is substituted by ethanolamine phosphate at C-6.
NCBI PubMed ID: 323005Journal NLM ID: 0107600Publisher: Oxford, UK: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
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3. Compound ID: 13069
a-L-Fucp-(1-3)-+ a-L-Fucp-(1-3)-+
| |
{{{-b-D-Galp-(1-4)-D-GlcpNAc-(1-?)-}}}b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
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Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 Le(x)-type 2 Le(x)
Compound class: LPS
Contained glycoepitopes: IEDB_130646,IEDB_130654,IEDB_130655,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_140108,IEDB_140122,IEDB_141500,IEDB_141794,IEDB_141807,IEDB_142489,IEDB_144556,IEDB_144562,IEDB_145669,IEDB_147455,IEDB_149557,IEDB_150092,IEDB_150939,IEDB_151531,IEDB_152214,IEDB_153529,IEDB_158533,IEDB_158550,IEDB_174333,IEDB_190606,IEDB_2151203,IEDB_2151204,IEDB_241103,IEDB_241107,IEDB_461720,IEDB_885811,IEDB_952752,SB_157,SB_165,SB_166,SB_173,SB_187,SB_195,SB_30,SB_7,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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4. Compound ID: 13070
b-D-GalpNAc-(1-3)-b-D-Galp-(1-3)-D-GlcpNAc-(1-?)-b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
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Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 LacNAc-type 1 A blood group
Compound class: LPS
Contained glycoepitopes: IEDB_130646,IEDB_130648,IEDB_135813,IEDB_136044,IEDB_137340,IEDB_137472,IEDB_137473,IEDB_1391962,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_143794,IEDB_150899,IEDB_151531,IEDB_157001,IEDB_157003,IEDB_1635950,IEDB_190606,IEDB_241103,IEDB_241107,IEDB_489984,IEDB_885811,IEDB_885816,SB_137,SB_156,SB_165,SB_166,SB_173,SB_187,SB_195,SB_21,SB_29,SB_30,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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5. Compound ID: 13071
a-L-Fucp-(1-4)-+ a-L-Fucp-(1-3)-+ a-L-Fucp-(1-3)-+
| | |
a-L-Fucp-(1-2)-b-D-Galp-(1-3)-D-GlcpNAc-(1-?)-{{{-b-D-Galp-(1-4)-D-GlcpNAc-(1-?)-}}}b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
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Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 Le(x)-type 1 Le(b)
Compound class: LPS
Contained glycoepitopes: IEDB_130646,IEDB_130652,IEDB_130653,IEDB_130654,IEDB_130697,IEDB_131182,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137354,IEDB_137472,IEDB_137776,IEDB_1391962,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_142489,IEDB_143794,IEDB_144556,IEDB_144562,IEDB_145669,IEDB_147455,IEDB_149554,IEDB_149556,IEDB_149557,IEDB_150092,IEDB_150899,IEDB_150939,IEDB_150948,IEDB_151531,IEDB_152214,IEDB_153529,IEDB_153553,IEDB_158533,IEDB_174333,IEDB_190606,IEDB_2151203,IEDB_2151204,IEDB_241103,IEDB_241107,IEDB_423096,IEDB_461709,IEDB_461719,IEDB_461720,IEDB_461723,IEDB_461724,IEDB_885811,IEDB_952752,SB_100,SB_137,SB_146,SB_154,SB_155,SB_157,SB_165,SB_166,SB_173,SB_187,SB_195,SB_29,SB_30,SB_7,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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6. Compound ID: 13072
a-L-Fucp-(1-3)-+ a-L-Fucp-(1-3)-+
| |
a-L-Fucp-(1-2)-{{{-b-D-Galp-(1-4)-D-GlcpNAc-(1-?)-}}}b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
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Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 Le(x)-type 2 Le(y)
Compound class: LPS
Contained glycoepitopes: IEDB_130644,IEDB_130646,IEDB_130654,IEDB_130655,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_140108,IEDB_140122,IEDB_141500,IEDB_141794,IEDB_141807,IEDB_142489,IEDB_143250,IEDB_144556,IEDB_144562,IEDB_145669,IEDB_147455,IEDB_149555,IEDB_149557,IEDB_149561,IEDB_150092,IEDB_150787,IEDB_150939,IEDB_150948,IEDB_151531,IEDB_152214,IEDB_153529,IEDB_153553,IEDB_158533,IEDB_158546,IEDB_158550,IEDB_174333,IEDB_190606,IEDB_2151203,IEDB_2151204,IEDB_241103,IEDB_241107,IEDB_461719,IEDB_461720,IEDB_461721,IEDB_885811,IEDB_952752,SB_147,SB_154,SB_157,SB_165,SB_166,SB_173,SB_187,SB_195,SB_30,SB_34,SB_7,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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7. Compound ID: 13073
a-L-Fucp-(1-4)-+ a-L-Fucp-(1-3)-+ a-L-Fucp-(1-3)-+
| | |
b-D-Galp-(1-3)-D-GlcpNAc-(1-?)-{{{-b-D-Galp-(1-4)-D-GlcpNAc-(1-?)-}}}b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
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Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 Le(x)-type 1 Le(a)
Compound class: LPS
Contained glycoepitopes: IEDB_130646,IEDB_130653,IEDB_130654,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391962,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_142489,IEDB_143794,IEDB_144556,IEDB_144562,IEDB_145669,IEDB_147455,IEDB_149556,IEDB_149557,IEDB_150092,IEDB_150899,IEDB_150939,IEDB_151531,IEDB_152214,IEDB_153529,IEDB_158533,IEDB_174333,IEDB_190606,IEDB_2151203,IEDB_2151204,IEDB_241103,IEDB_241107,IEDB_423096,IEDB_461720,IEDB_461723,IEDB_885811,IEDB_952752,SB_137,SB_155,SB_157,SB_165,SB_166,SB_173,SB_187,SB_195,SB_29,SB_30,SB_7,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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8. Compound ID: 13074
a-L-Fucp-(1-3)-+ a-L-Fucp-(1-3)-+
| |
a-L-Fucp-(1-2)-b-D-Galp-(1-3)-D-GlcpNAc-(1-?)-{{{-b-D-Galp-(1-4)-D-GlcpNAc-(1-?)-}}}b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
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Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 Le(x)-type 1 Le(d)
Compound class: LPS
Contained glycoepitopes: IEDB_130646,IEDB_130652,IEDB_130654,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391962,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_142489,IEDB_143794,IEDB_144556,IEDB_144562,IEDB_145669,IEDB_147455,IEDB_149554,IEDB_149557,IEDB_150092,IEDB_150899,IEDB_150939,IEDB_150948,IEDB_151531,IEDB_152214,IEDB_153529,IEDB_153553,IEDB_158533,IEDB_174333,IEDB_190606,IEDB_2151203,IEDB_2151204,IEDB_241103,IEDB_241107,IEDB_461709,IEDB_461719,IEDB_461720,IEDB_885811,IEDB_952752,SB_100,SB_137,SB_154,SB_157,SB_165,SB_166,SB_173,SB_187,SB_195,SB_29,SB_30,SB_7,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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