Found 9 structures.
Displayed structures from 1 to 9
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1. Compound ID: 6193
Structure type: oligomer
Compound class: LOS
Contained glycoepitopes: IEDB_130646,IEDB_135813,IEDB_136044,IEDB_137340,IEDB_137472,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_151531,IEDB_190606,IEDB_241107,SB_165,SB_166,SB_187,SB_195,SB_30,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 2769
Yamasaki R, Nasholds W, Schneider H, Apicella MA "Epitope expression and partial structural characterization of F62 lipooligosaccharide (LOS) of Neisseria gonorrhoeae: IgM monoclonal antibodies (3F11 and 1-1-M) recognize non-reducing termini of the LOS components" -
Molecular Immunology 28 (1991) 1233-1242
Journal NLM ID: 7905289Publisher: Elsevier
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2. Compound ID: 6582
|
Rib-ol-(1--P--3)--+ EtN-(1--P--6)--+
| |
-?)-/Variants 0/-GlcpNAc-(1-3)-Glcp-(1-3)-GlcpNAc-(1-
/Variants 0/ is:
Galp-(1-4)-
OR (exclusively)
Galp-(1-3)- |
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Structure type: structural motif or average structure
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_114703,IEDB_120354,IEDB_123890,IEDB_130646,IEDB_135813,IEDB_136044,IEDB_136906,IEDB_137340,IEDB_137472,IEDB_1391962,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_142488,IEDB_143794,IEDB_144998,IEDB_144999,IEDB_145003,IEDB_146664,IEDB_150899,IEDB_151528,IEDB_151531,IEDB_167070,IEDB_190606,IEDB_241103,IEDB_241107,IEDB_241118,IEDB_885811,IEDB_983931,SB_137,SB_165,SB_166,SB_173,SB_187,SB_192,SB_195,SB_29,SB_30,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 2969
Gmeiner J "The ribitol-phosphate-containing lipopolysaccharide from Proteus mirabilis, strain D52. Investigations of O-specific chains" -
European Journal of Biochemistry 74 (1977) 171-180
A soluble hydrophilic lipopolysaccharide, termed lipopolysaccharide II, isolated from Proteus mirabilis, strain D52 contained N-acetylglucosamine, glucose, galactose, ribitol phosphate and ethanolamine phosphate as constituents of the O-specific polysaccharide. Periodate oxidation studies were carried out on the polymer before and after dephosphorylation with hydrofluoric acid and on oligosaccharides derived from the polymer by partial acid hydrolysis. The results obtained indicate that the polysaccharide chain consists of the chemical repeating unit Gal-1,3(4)-GlcNAc-1,3-Glc-1,3-GlcNAc-, where GlcNAc stands for N-acetylglucosamine. Whereas the galactose residue is substituted at C-3 by ribitol phosphate, the glucose is substituted by ethanolamine phosphate at C-6.
NCBI PubMed ID: 323005Journal NLM ID: 0107600Publisher: Oxford, UK: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
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3. Compound ID: 13069
|
a-L-Fucp-(1-3)-+ a-L-Fucp-(1-3)-+
| |
{{{-b-D-Galp-(1-4)-D-GlcpNAc-(1-?)-}}}b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
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Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 Le(x)-type 2 Le(x)
Compound class: LPS
Contained glycoepitopes: IEDB_130646,IEDB_130654,IEDB_130655,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_140108,IEDB_140122,IEDB_141500,IEDB_141794,IEDB_141807,IEDB_142489,IEDB_144556,IEDB_144562,IEDB_145669,IEDB_147455,IEDB_149557,IEDB_150092,IEDB_150939,IEDB_151531,IEDB_152214,IEDB_153529,IEDB_158533,IEDB_158550,IEDB_174333,IEDB_190606,IEDB_2151203,IEDB_2151204,IEDB_241103,IEDB_241107,IEDB_461720,IEDB_885811,IEDB_952752,SB_157,SB_165,SB_166,SB_173,SB_187,SB_195,SB_30,SB_7,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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4. Compound ID: 13070
|
b-D-GalpNAc-(1-3)-b-D-Galp-(1-3)-D-GlcpNAc-(1-?)-b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
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Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 LacNAc-type 1 A blood group
Compound class: LPS
Contained glycoepitopes: IEDB_130646,IEDB_130648,IEDB_135813,IEDB_136044,IEDB_137340,IEDB_137472,IEDB_137473,IEDB_1391962,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_143794,IEDB_150899,IEDB_151531,IEDB_157001,IEDB_157003,IEDB_1635950,IEDB_190606,IEDB_241103,IEDB_241107,IEDB_489984,IEDB_885811,IEDB_885816,SB_137,SB_156,SB_165,SB_166,SB_173,SB_187,SB_195,SB_21,SB_29,SB_30,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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5. Compound ID: 13071
|
a-L-Fucp-(1-4)-+ a-L-Fucp-(1-3)-+ a-L-Fucp-(1-3)-+
| | |
a-L-Fucp-(1-2)-b-D-Galp-(1-3)-D-GlcpNAc-(1-?)-{{{-b-D-Galp-(1-4)-D-GlcpNAc-(1-?)-}}}b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
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Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 Le(x)-type 1 Le(b)
Compound class: LPS
Contained glycoepitopes: IEDB_130646,IEDB_130652,IEDB_130653,IEDB_130654,IEDB_130697,IEDB_131182,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137354,IEDB_137472,IEDB_137776,IEDB_1391962,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_142489,IEDB_143794,IEDB_144556,IEDB_144562,IEDB_145669,IEDB_147455,IEDB_149554,IEDB_149556,IEDB_149557,IEDB_150092,IEDB_150899,IEDB_150939,IEDB_150948,IEDB_151531,IEDB_152214,IEDB_153529,IEDB_153553,IEDB_158533,IEDB_174333,IEDB_190606,IEDB_2151203,IEDB_2151204,IEDB_241103,IEDB_241107,IEDB_423096,IEDB_461709,IEDB_461719,IEDB_461720,IEDB_461723,IEDB_461724,IEDB_885811,IEDB_952752,SB_100,SB_137,SB_146,SB_154,SB_155,SB_157,SB_165,SB_166,SB_173,SB_187,SB_195,SB_29,SB_30,SB_7,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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6. Compound ID: 13072
|
a-L-Fucp-(1-3)-+ a-L-Fucp-(1-3)-+
| |
a-L-Fucp-(1-2)-{{{-b-D-Galp-(1-4)-D-GlcpNAc-(1-?)-}}}b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
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Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 Le(x)-type 2 Le(y)
Compound class: LPS
Contained glycoepitopes: IEDB_130644,IEDB_130646,IEDB_130654,IEDB_130655,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_140108,IEDB_140122,IEDB_141500,IEDB_141794,IEDB_141807,IEDB_142489,IEDB_143250,IEDB_144556,IEDB_144562,IEDB_145669,IEDB_147455,IEDB_149555,IEDB_149557,IEDB_149561,IEDB_150092,IEDB_150787,IEDB_150939,IEDB_150948,IEDB_151531,IEDB_152214,IEDB_153529,IEDB_153553,IEDB_158533,IEDB_158546,IEDB_158550,IEDB_174333,IEDB_190606,IEDB_2151203,IEDB_2151204,IEDB_241103,IEDB_241107,IEDB_461719,IEDB_461720,IEDB_461721,IEDB_885811,IEDB_952752,SB_147,SB_154,SB_157,SB_165,SB_166,SB_173,SB_187,SB_195,SB_30,SB_34,SB_7,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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7. Compound ID: 13073
|
a-L-Fucp-(1-4)-+ a-L-Fucp-(1-3)-+ a-L-Fucp-(1-3)-+
| | |
b-D-Galp-(1-3)-D-GlcpNAc-(1-?)-{{{-b-D-Galp-(1-4)-D-GlcpNAc-(1-?)-}}}b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
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Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 Le(x)-type 1 Le(a)
Compound class: LPS
Contained glycoepitopes: IEDB_130646,IEDB_130653,IEDB_130654,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391962,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_142489,IEDB_143794,IEDB_144556,IEDB_144562,IEDB_145669,IEDB_147455,IEDB_149556,IEDB_149557,IEDB_150092,IEDB_150899,IEDB_150939,IEDB_151531,IEDB_152214,IEDB_153529,IEDB_158533,IEDB_174333,IEDB_190606,IEDB_2151203,IEDB_2151204,IEDB_241103,IEDB_241107,IEDB_423096,IEDB_461720,IEDB_461723,IEDB_885811,IEDB_952752,SB_137,SB_155,SB_157,SB_165,SB_166,SB_173,SB_187,SB_195,SB_29,SB_30,SB_7,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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8. Compound ID: 13074
|
a-L-Fucp-(1-3)-+ a-L-Fucp-(1-3)-+
| |
a-L-Fucp-(1-2)-b-D-Galp-(1-3)-D-GlcpNAc-(1-?)-{{{-b-D-Galp-(1-4)-D-GlcpNAc-(1-?)-}}}b-D-Galp-(1-4)-D-GlcpNAc-(1--/core-Trio(GlcNAc-Fuc-Hep)/ |
Show graphically |
Structure type: fragment of a bigger structure
Aglycon: core-Trio(GlcNAc-Fuc-Hep)
Trivial name: type 2 Le(x)-type 1 Le(d)
Compound class: LPS
Contained glycoepitopes: IEDB_130646,IEDB_130652,IEDB_130654,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391962,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_142489,IEDB_143794,IEDB_144556,IEDB_144562,IEDB_145669,IEDB_147455,IEDB_149554,IEDB_149557,IEDB_150092,IEDB_150899,IEDB_150939,IEDB_150948,IEDB_151531,IEDB_152214,IEDB_153529,IEDB_153553,IEDB_158533,IEDB_174333,IEDB_190606,IEDB_2151203,IEDB_2151204,IEDB_241103,IEDB_241107,IEDB_461709,IEDB_461719,IEDB_461720,IEDB_885811,IEDB_952752,SB_100,SB_137,SB_154,SB_157,SB_165,SB_166,SB_173,SB_187,SB_195,SB_29,SB_30,SB_7,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 5179
Li H, Tang H, Debowski AW, Stubbs KA, Marshall BJ, Benghezal M "Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains" -
Toxins 10(9) (2018) 364
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc-Gal-Hep-III-Hep-II-Hep-I-KDO) and its attached trisaccharide (Trio, GlcNAc-Fuc-Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan?heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.
Lipopolysaccharide, structure, Helicobacter pylori
NCBI PubMed ID: 30205541Publication DOI: 10.3390/toxins10090364Journal NLM ID: 101530765Publisher: Basel: MDPI
Correspondence: H.T.
; M.B.
Institutions: West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China, Helicobacter pylori Research Laboratory, School of Biomedical Sciences, Marshall Centre for Infectious Disease Research and Training, University of Western Australia, Nedlands, WA 6009, Australia, School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia
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9. Compound ID: 15290
|
Subst-(1-2)-EtN-(1--P--6)--a-D-Manp-(1-2)-a-D-Manp-(1-6)-+ Ste-(1-2)-+ Ste-(1-1)-+
| | |
a-Neup5Ac-(2-3)-{{{-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-?)-}}}b-D-Galp-(1-4)-b-D-GlcpNAc-(1-?)-a-D-Manp-(1-4)-a-D-GlcpN-(1-6)-myoIno-(1--P--3)--Gro
Subst = protein |
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Structure type: structural motif or average structure
Trivial name: procyclin glycoprotein
Compound class: GPI-anchor
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130646,IEDB_130655,IEDB_130697,IEDB_130701,IEDB_135813,IEDB_136044,IEDB_136104,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_140108,IEDB_140116,IEDB_140122,IEDB_141793,IEDB_141794,IEDB_141807,IEDB_141829,IEDB_143242,IEDB_143632,IEDB_144983,IEDB_144993,IEDB_146100,IEDB_149174,IEDB_150933,IEDB_150939,IEDB_151531,IEDB_152206,IEDB_153220,IEDB_153529,IEDB_158533,IEDB_158550,IEDB_158552,IEDB_190606,IEDB_241107,IEDB_423120,IEDB_423128,IEDB_474450,IEDB_534865,IEDB_983930,SB_115,SB_116,SB_131,SB_136,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_187,SB_191,SB_195,SB_196,SB_198,SB_30,SB_39,SB_44,SB_67,SB_68,SB_7,SB_72,SB_84,SB_88
The structure is contained in the following publication(s):
- Article ID: 5943
Heng J, Naderer T, Ralph SA, McConville MJ "Glycosylated compounds of parasitic protozoa" -
Book: Microbial Glycobiology (series: Structures, Relevance and Applications) (2010) 203-231
This chapter describes the range of glycan structures and pathways that are found in different parasitic protozoa. All parasitic protists express a range of glycoconjugates that form protective protein-rich or carbohydrate-rich surface coats. Protein-rich coats are typically found on developmental stages that inhabit nonhydrolytic niches, such as the bloodstream and nonacidified intracellular vacuoles. These coats are commonly dominated by a limited repertoire of antigenically diverse proteins that are commonly, but not always, glycosylphosphatidylinositol- (GPI-) anchored and modified with N- or O-glycans. Carbohydrate-rich coats are commonly found on developmental stages that dwell within hydrolytic environments, such as vertebrate and arthropod digestive tracts and lysosomal vacuoles. These coats are dominated by GPI-anchored glycoproteins that are heavily modified with N-glycans, O-glycans, or phosphoglycans. Free GPI glycolipids (not attached to protein) can also be abundant or dominant components of these coats. Some parasitic protists can also form highly resistant cyst stages encased within polysaccharide-rich cell walls. Considerable progress has been made in defining the structures of the surface and intracellular glycans of the parasitic protists, their biosynthesis and the role that individual components play in parasite infectivity.
O-glycosylation, Glycosylphosphatidylinositol, N-glycosylation, protozoan parasites, Phosphoglycosylation
Publication DOI: 10.1016/B978-0-12-374546-0.00012-2Publisher: Amsterdam: Elsevier
Correspondence: malcolmm@unimelb.edu.au
Editors: Moran A
Institutions: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia
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