Show legend Show as text

Structure type: polymer chemical repeating unit ; n=4
Trivial name: chondroitin sulfate
Compound class: mucopolysaccharide
Contained glycoepitopes: IEDB_115136,IEDB_130648,IEDB_136108,IEDB_137473,IEDB_140630,IEDB_143643,IEDB_153510,IEDB_423153

• Article ID: 3316
  Yu H, Chen X "Carbohydrate post-glycosylational modifications" - Organic and Biomolecular Chemistry 5(6) (2007) 865-872
  

  Carbohydrate modification is a common phenomenon in nature. Many carbohydrate modifications such as some epimerization, O-acetylation, O-sulfation, O-methylation, N-deacetylation, and N-sulfation, take place after the formation of oligosaccharide or polysaccharide backbones. These modifications can be categorized as carbohydrate post-glycosylational modifications (PGMs). Carbohydrate PGMs further extend the complexity of the structures and the synthesis of carbohydrates and glycoconjugates. They also increase the capacity of the biological regulation that is achieved by finely tuning the structures of carbohydrates. Developing efficient methods to obtain structurally defined naturally occurring oligosaccharides, polysaccharides, and glycoconjugates with carbohydrate PGMs is essential for understanding the biological significance of carbohydrate PGMs. Combined with high-throughput screening methods, synthetic carbohydrates with PGMs are invaluable probes in structure-activity relationship studies. We illustrate here several classes of carbohydrates with PGMs and their applications. Recent progress in chemical, enzymatic, and chemoenzymatic syntheses of these carbohydrates and their derivatives are also presented

  synthesis, polysaccharides, regulation, glycoconjugates, enzymatic, modification, structure-activity relationship, methods, epimerization

  Publication DOI: 10.1039/b700034k
  Journal NLM ID: 101154995
  Publisher: The Royal Society of Chemistry
  Correspondence: chen@chem.ucdavis.edu
  Institutions: Department of Chemistry, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA
  
   
  
  Homo sapiens
  CSDB ID 21670 (all data & tools)

Show legend Show as text

Structure type: polymer chemical repeating unit ; n=4
Trivial name: chondroitin sulfate
Compound class: mucopolysaccharide
Contained glycoepitopes: IEDB_115136,IEDB_130648,IEDB_136108,IEDB_137473,IEDB_140630,IEDB_143642,IEDB_143643,IEDB_153510,IEDB_423153

• Article ID: 3316
  Yu H, Chen X "Carbohydrate post-glycosylational modifications" - Organic and Biomolecular Chemistry 5(6) (2007) 865-872
  

  Carbohydrate modification is a common phenomenon in nature. Many carbohydrate modifications such as some epimerization, O-acetylation, O-sulfation, O-methylation, N-deacetylation, and N-sulfation, take place after the formation of oligosaccharide or polysaccharide backbones. These modifications can be categorized as carbohydrate post-glycosylational modifications (PGMs). Carbohydrate PGMs further extend the complexity of the structures and the synthesis of carbohydrates and glycoconjugates. They also increase the capacity of the biological regulation that is achieved by finely tuning the structures of carbohydrates. Developing efficient methods to obtain structurally defined naturally occurring oligosaccharides, polysaccharides, and glycoconjugates with carbohydrate PGMs is essential for understanding the biological significance of carbohydrate PGMs. Combined with high-throughput screening methods, synthetic carbohydrates with PGMs are invaluable probes in structure-activity relationship studies. We illustrate here several classes of carbohydrates with PGMs and their applications. Recent progress in chemical, enzymatic, and chemoenzymatic syntheses of these carbohydrates and their derivatives are also presented

  synthesis, polysaccharides, regulation, glycoconjugates, enzymatic, modification, structure-activity relationship, methods, epimerization

  Publication DOI: 10.1039/b700034k
  Journal NLM ID: 101154995
  Publisher: The Royal Society of Chemistry
  Correspondence: chen@chem.ucdavis.edu
  Institutions: Department of Chemistry, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA
  
   
  
  Homo sapiens
  CSDB ID 21671 (all data & tools)

Show legend Show as text

Structure type: polymer chemical repeating unit
Trivial name: chondroitin sulfate
Compound class: mucopolysaccharide
Contained glycoepitopes: IEDB_115136,IEDB_130648,IEDB_136108,IEDB_137473,IEDB_140630,IEDB_143642,IEDB_153510,IEDB_423153

• Article ID: 3316
  Yu H, Chen X "Carbohydrate post-glycosylational modifications" - Organic and Biomolecular Chemistry 5(6) (2007) 865-872
  

  Carbohydrate modification is a common phenomenon in nature. Many carbohydrate modifications such as some epimerization, O-acetylation, O-sulfation, O-methylation, N-deacetylation, and N-sulfation, take place after the formation of oligosaccharide or polysaccharide backbones. These modifications can be categorized as carbohydrate post-glycosylational modifications (PGMs). Carbohydrate PGMs further extend the complexity of the structures and the synthesis of carbohydrates and glycoconjugates. They also increase the capacity of the biological regulation that is achieved by finely tuning the structures of carbohydrates. Developing efficient methods to obtain structurally defined naturally occurring oligosaccharides, polysaccharides, and glycoconjugates with carbohydrate PGMs is essential for understanding the biological significance of carbohydrate PGMs. Combined with high-throughput screening methods, synthetic carbohydrates with PGMs are invaluable probes in structure-activity relationship studies. We illustrate here several classes of carbohydrates with PGMs and their applications. Recent progress in chemical, enzymatic, and chemoenzymatic syntheses of these carbohydrates and their derivatives are also presented

  synthesis, polysaccharides, regulation, glycoconjugates, enzymatic, modification, structure-activity relationship, methods, epimerization

  Publication DOI: 10.1039/b700034k
  Journal NLM ID: 101154995
  Publisher: The Royal Society of Chemistry
  Correspondence: chen@chem.ucdavis.edu
  Institutions: Department of Chemistry, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA
  
   
  
  Homo sapiens
  CSDB ID 21672 (all data & tools)