Found 3 structures.
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1. Compound ID: 840
a-L-Fucp-(1-3)-+
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-D-GlcNAc
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S-6)-+ |
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Structure type: oligomer
Trivial name: 6-sulfo-sialyl-LeX
Contained glycoepitopes: IEDB_130646,IEDB_130654,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_140108,IEDB_140122,IEDB_141586,IEDB_141794,IEDB_141807,IEDB_142354,IEDB_142489,IEDB_144562,IEDB_145669,IEDB_146100,IEDB_149174,IEDB_149557,IEDB_150092,IEDB_150933,IEDB_151531,IEDB_152214,IEDB_174333,IEDB_190606,IEDB_241119,IEDB_241120,IEDB_241127,IEDB_423120,IEDB_461720,SB_115,SB_116,SB_128,SB_129,SB_131,SB_157,SB_165,SB_166,SB_170,SB_171,SB_172,SB_187,SB_195,SB_30,SB_39,SB_68,SB_7,SB_84,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 230
Feizi T "Progress in deciphering the information content of the 'glycome' - a crescendo in the closing years of the millennium" -
Glycoconjugate Journal 17(7-9) (2000) 553-565
The closing years of the second millennium have been uplifting for carbohydrate biology. Optimism that oligosaccharide sequences are bearers of crucial biological information has been borne out by the constellation of efforts of carbohydrate chemists, biochemists, immunochemists, and cell- and molecular biologists. The direct involvement of specific oligosaccharide sequences in protein targeting and folding, and in mechanisms of infection, inflammation and immunity is now unquestioned. With the emergence of families of proteins with carbohydrate-binding activities, assignments of information content for defined oligosaccharide sequences will become more common, but the pinpointing and elucidation of the bioactive domains on oligosaccharides will continue to pose challenges even to the most experienced carbohydrate biologists. The neoglycolipid technology incorporates some of the key requirements for this challenge: namely the resolution of complex glycan mixtures, and ligand binding coupled with sequence determination by mass spectrometry.
monoclonal antibodies, mass spectrometry, blood group antigen, carbohydrate ligands, differentiation antigens, embryonic development, galectins, inflammation, leukocyte adhesion, neoglycolipids, oligosaccharide ligands, oligosaccharid probes, selectins
NCBI PubMed ID: 11421348Journal NLM ID: 8603310Publisher: Kluwer Academic Publishers
Correspondence: t.feizi@ic.ac.uk
Institutions: The Glycosciences Laboratory, Imperial College School of Medicine, Harrow, United Kingdom
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2. Compound ID: 841
a-L-Fucp-(1-3)-+
|
S-6)-+ |
| |
a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-D-GlcNAc
|
S-6)-+ |
Show graphically |
Structure type: oligomer
Trivial name: 6,6'-sulfo-sialyl-LeX
Contained glycoepitopes: IEDB_130646,IEDB_130654,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_140108,IEDB_140122,IEDB_141586,IEDB_141794,IEDB_141807,IEDB_142354,IEDB_142489,IEDB_144562,IEDB_145669,IEDB_146100,IEDB_149174,IEDB_149557,IEDB_150092,IEDB_150933,IEDB_151531,IEDB_152214,IEDB_174333,IEDB_190606,IEDB_241119,IEDB_241120,IEDB_241127,IEDB_423120,IEDB_461720,SB_115,SB_116,SB_128,SB_129,SB_131,SB_157,SB_165,SB_166,SB_170,SB_171,SB_172,SB_187,SB_195,SB_30,SB_39,SB_68,SB_7,SB_84,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 230
Feizi T "Progress in deciphering the information content of the 'glycome' - a crescendo in the closing years of the millennium" -
Glycoconjugate Journal 17(7-9) (2000) 553-565
The closing years of the second millennium have been uplifting for carbohydrate biology. Optimism that oligosaccharide sequences are bearers of crucial biological information has been borne out by the constellation of efforts of carbohydrate chemists, biochemists, immunochemists, and cell- and molecular biologists. The direct involvement of specific oligosaccharide sequences in protein targeting and folding, and in mechanisms of infection, inflammation and immunity is now unquestioned. With the emergence of families of proteins with carbohydrate-binding activities, assignments of information content for defined oligosaccharide sequences will become more common, but the pinpointing and elucidation of the bioactive domains on oligosaccharides will continue to pose challenges even to the most experienced carbohydrate biologists. The neoglycolipid technology incorporates some of the key requirements for this challenge: namely the resolution of complex glycan mixtures, and ligand binding coupled with sequence determination by mass spectrometry.
monoclonal antibodies, mass spectrometry, blood group antigen, carbohydrate ligands, differentiation antigens, embryonic development, galectins, inflammation, leukocyte adhesion, neoglycolipids, oligosaccharide ligands, oligosaccharid probes, selectins
NCBI PubMed ID: 11421348Journal NLM ID: 8603310Publisher: Kluwer Academic Publishers
Correspondence: t.feizi@ic.ac.uk
Institutions: The Glycosciences Laboratory, Imperial College School of Medicine, Harrow, United Kingdom
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3. Compound ID: 7318
a-L-Fucp-(1-3)-+
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a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1--/unidentified group/
|
S-6)-+ |
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Structure type: oligomer
Aglycon: unidentified group
Trivial name: 6-sulfo sialyl Lex
Contained glycoepitopes: IEDB_130646,IEDB_130654,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_140108,IEDB_140122,IEDB_141586,IEDB_141794,IEDB_141807,IEDB_142354,IEDB_142489,IEDB_144562,IEDB_145669,IEDB_146100,IEDB_149174,IEDB_149557,IEDB_150092,IEDB_150933,IEDB_151531,IEDB_152214,IEDB_174333,IEDB_190606,IEDB_241119,IEDB_241120,IEDB_241127,IEDB_423120,IEDB_461720,SB_115,SB_116,SB_128,SB_129,SB_131,SB_157,SB_165,SB_166,SB_170,SB_171,SB_172,SB_187,SB_195,SB_30,SB_39,SB_68,SB_7,SB_84,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 3316
Yu H, Chen X "Carbohydrate post-glycosylational modifications" -
Organic and Biomolecular Chemistry 5(6) (2007) 865-872
Carbohydrate modification is a common phenomenon in nature. Many carbohydrate modifications such as some epimerization, O-acetylation, O-sulfation, O-methylation, N-deacetylation, and N-sulfation, take place after the formation of oligosaccharide or polysaccharide backbones. These modifications can be categorized as carbohydrate post-glycosylational modifications (PGMs). Carbohydrate PGMs further extend the complexity of the structures and the synthesis of carbohydrates and glycoconjugates. They also increase the capacity of the biological regulation that is achieved by finely tuning the structures of carbohydrates. Developing efficient methods to obtain structurally defined naturally occurring oligosaccharides, polysaccharides, and glycoconjugates with carbohydrate PGMs is essential for understanding the biological significance of carbohydrate PGMs. Combined with high-throughput screening methods, synthetic carbohydrates with PGMs are invaluable probes in structure-activity relationship studies. We illustrate here several classes of carbohydrates with PGMs and their applications. Recent progress in chemical, enzymatic, and chemoenzymatic syntheses of these carbohydrates and their derivatives are also presented
synthesis, polysaccharides, regulation, glycoconjugates, enzymatic, modification, structure-activity relationship, methods, epimerization
Publication DOI: 10.1039/b700034kJournal NLM ID: 101154995Publisher: The Royal Society of Chemistry
Correspondence: chen@chem.ucdavis.edu
Institutions: Department of Chemistry, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA
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